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OBJECTIVES To examine the diagnostic validity of bone alkaline phosphatase (BAP) in serum (a marker of bone formation) and of urinary excretion of pyridinium cross-links (PYR) (a marker of bone resorption) for detection of bone metastases. DESIGN AND METHODS Two heterogeneous immunoassays were employed for determination of BAP mass concentrations(More)
We report on the diagnostic validity of the serum concentrations of the C-terminal propeptide of type I procollagen (a marker of bone formation) and of the urinary excretion of deoxypyridinoline (a marker of bone resorption) in a consecutive series of 89 tumour patients who were routinely examined by 99mTc-methylene bisphosphonate bone scintigraphy for(More)
Protein tertiary structure prediction (PSP) is one of the most challenging problems in bioinformatics. Different methods have been introduced to solve this problem so far, but PSP is computationally intensive and belongs to the NP-hard class. One of the best solutions to accelerate PSP is the use of a massively parallel processing architecture, such(More)
The integrative and cooperative nature of protein structure involves the assessment of topological and global features of constituent parts. Network concept takes complete advantage of both of these properties in the analysis concomitantly. High compatibility to structural concepts or physicochemical properties in addition to exploiting a remarkable(More)
This paper describes the research and development of Tourism Expert System (TES). A prototype system has been designed and developed with a knowledge base containing more than 20 cities and 150 rules for helping tourists to choose best destination town have maximum matching with their important requests. This paper without using fuzzyCLIPS presents a novel(More)
One of the main problems in Bioinformatics is the prediction of protein tertiary structure from its amino acid sequence. This problem is computationally complex and belongs to the NP-hard class. Although these years many algorithms and methods have been introduced, this problem is still an open area for research. In this paper we discuss the most important(More)
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