Hala Chaaban

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Extracellular histones are mediators of tissue injury and organ dysfunction; therefore they constitute potential therapeutic targets in sepsis, inflammation, and thrombosis. Histone cytotoxicity in vitro decreases in the presence of plasma. Here, we demonstrate that plasma inter-α inhibitor protein (IAIP) neutralizes the cytotoxic effects of histones and(More)
This report describes the use of oral administration of sildenafil in an 8-year-old girl with Takayasu arteritis (TA) and severe left big toe ischemia. An 8-year-old girl who presented with history of pain in her lower extremities for several weeks. On physical exam, she had no signs of arthritis; she was managed with antiinflammatory drugs and short(More)
Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death. Here we tested the effect of RA101295, a 2-kDa macrocyclic peptide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in(More)
OBJECTIVES To determine the percentage of detectable tobramycin troughs and acute kidney injury in critically ill children without cystic fibrosis on inhaled therapy. DESIGN Historic cohort. SETTING Academic hospital. PATIENTS Forty children less than 18 years receiving inhaled tobramycin across 6.5 years. INTERVENTIONS None. MEASUREMENTS AND MAIN(More)
This report presents a case of short-chain acyl-coenzyme A (CoA) dehydrogenase deficiency with a previously unreported presentation with brain malformations and infantile spasms. This female infant developed repeated tonic clonic seizures at the age of 3(1/2) months. She subsequently developed West syndrome at the age of 4 months. Her electroencephalogram(More)
We evaluated Inter-alpha inhibitor proteins (IaIp) as a diagnostic marker in neonatal sepsis. Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121+/-71 mg/L) than in the non-septic group (322+/-91 mg/L). The optimal cutoff value with the receiver operating characteristic(More)
Sepsis-induced inflammation of the lung leads to acute respiratory distress syndrome (ARDS), which may trigger persistent fibrosis. The pathology of ARDS is complex and poorly understood, and the therapeutic approaches are limited. We used a baboon model of Escherichia coli sepsis that mimics the complexity of human disease to study the pathophysiology of(More)
2007 Section on Perinatal Pediatrics Annual Program AAP National Conference & Exhibition San Francisco, CA Journal of Perinatology (2007) 27, 626–660; doi:10.1038/sj.jp.7211818 Friday, October 26, 2007 1–5:00 pm Organization of Neonatal Training Program Directors (ONTPD) Judy Aschner, ONTPD Chair SECTION ON PERINATAL PEDIATRICS Saturday, October 26, 2007(More)
OBJECTIVES To compare inter-alpha inhibitor protein (IaIp) levels in neonates with proven necrotizing enterocolitis (NEC) and neonates with other, nonspecific abdominal disorders. STUDY DESIGN This was a prospective observational study of neonates in the neonatal intensive care unit. NEC was diagnosed according to Bell's staging criteria. The nNeonates in(More)
The neonatal gastrointestinal tract is a site of intense anabolic and metabolic activity, as it is responsible for the assimilation of nutritional intake and exhibits accelerated growth shortly after birth. The hypermetabolic state of the gastrointestinal tract requires sufficient blood flow and oxygen delivery to sustain adequate oxygen consumption to meet(More)