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At the request of the Food and Drug Administration (FDA) and with its funding, the Panel on the Handling of Missing Data in Clinical Trials was created by the National Research Council's Committee on National Statistics. This panel recently published a report(1) with recommendations that will be of use not only to the FDA but also to the entire clinical(More)
We have developed an in vitro assay for examining the neural tube/notochord influence on somite myogenesis. No cells committed to myogenesis (operationally defined as immunopositive staining for myosin heavy chain after a 48-hr culture period) are present in the most caudal somites (I-V) of stage 8-11 chicken embryos, whereas by stage 14-15, the most caudal(More)
Previous studies have demonstrated that the neural tube/notochord complex is required for skeletal muscle development within somites. In order to explore the localization of myogenic inducing signals within the neural tube, dorsal or ventral neural tube halves were cultured in contact with single somites or pieces of segmental plate mesoderm. Somites and(More)
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering , and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special(More)
The well known time-order error (TOE) phenomenon is studied in the light of a model arising from Luce's (2004) global psychophysical theory which asserts that when a respondent matches z to be p times a reference signal x, this amounts to satisfying the equation W (p) = ψ(z) − ψ(ρ) ψ(x) − ψ(ρ) , where ψ is a psychophysical function, W is a numerical(More)
In writing my essay I presumed I was voicing, with a few novel nuances, a nearly universal attitude among contemporary statistical practitioners—at least among those who had wrestled with the incompatibility of Bayesian and frequentist logic. Then David Madigan collected commentaries from several thoughtful and accomplished statisticians. Not only do I know(More)
Rob Kass presents a fascinating vision of a " post "-Bayes/frequentist-controversy world in which practical utility of statistical models is the guiding principle for statistical inference. I agree with Kass on many points. In particular, Kass is correct (in my opinion) when he notes that much modern statistical work develops statistical models (the(More)
Dear Vice Chancellor Bryant; Attached, please find the renewal proposal for the Center for Organizational Research (COR) and associated supporting information in the appendices. As you will see the center is very active and has become an important part of the research environment for people who study organizations at UCI and, indeed, beyond UCI. I am the(More)
The main theme of this thesis is the study of the asymptotic and computational aspects of clustering analysis for samples of iid observations in an effort to improve upon the older methods. We are concerned with hierarchical clustering methods and we focus on the single link method. First, a detailed general framework is developed to deal with hierarchical(More)