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We derive models of the effects of periodic, discrete dosing or constant dosing of antibiotics on a bacterial population whose growth is checked by nutrient-limitation and possibly by host defenses. Mathematically rigorous results providing sufficient conditions for treatment success, i.e., the elimination of the bacteria, as well as for treatment failure,(More)
In this article, we study the global dynamics of a discrete two-dimensional competition model. We give sufficient conditions on the persistence of one species and the existence of local asymptotically stable interior period-2 orbit for this system. Moreover, we show that for a certain parameter range, there exists a compact interior attractor that attracts(More)
We develop a simple mathematical model of a bacterial colonization of host tissue which takes account of nutrient availability and innate immune response. The model features an infection-free state which is locally but not globally attracting implying that a super-threshold bacterial inoculum is required for successful colonization and tissue infection. A(More)
Biological systematics studies suggest that species are discretized in niche space. That is, rather than seeing a continuum of organism types with respect to continuous environmental variations, observers instead find discrete species or clumps of species, with one clump separated from another in niche space by a gap. Here, using a simple one dimensional(More)
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