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Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR), commonly the deletion of residue Phe-508 (DeltaF508) in the first nucleotide-binding domain (NBD1), which results in a severe reduction in the population of functional channels at the epithelial cell surface. Previous studies employing incomplete NBD1(More)
The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA has been determined at 2.4 A resolution. Mammalian Nova antigens (1 and 2) constitute an important family of regulators of RNA metabolism in neurons, first identified using sera from cancer patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia(More)
Tested mediator and moderator models of hope, coping, and adjustment in 39 children with sickle cell disease. In home interviews parents provided information on demographics and functional adjustment. Children self-reported levels of hope, coping strategies, and psychological adjustment. Coping strategies moderated, but did not mediate, the relationship(More)
 In this paper, we propose a method to improve sound classification performance by combining signal features, derived from the time-frequency spectrogram, with human perception. The method presented herein exploits an artificial neural network (ANN) and learns the signal features based on the human perception knowledge. The proposed method is applied to a(More)
Apolipoprotein E4 (APOE4) genotype is a risk factor for poor outcome after traumatic brain injury (TBI), particularly in young patients, but the underlying mechanisms are not known. By analogy to effects of APOE4 on the risk of Alzheimer disease (AD), the APOE genotype may influence β-amyloid (Aβ) and tau deposition after TBI. To test this hypothesis, we(More)