Hajime Yokomizo

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Schwannomas occurring in the gastrointestinal tract are rare, and among them, schwannomas of the large intestine are extremely rare. In this paper, we report a case of a macroscopically atypical schwannoma of the transverse colon. The case is a female aged 67. Stool occult blood test was positive, and colonoscopy revealed a protruded lesion resembling a(More)
UNLABELLED The distance of tumor invasion beyond the outer border of the muscularis propria (DBM) was measured whether it would be useful as a prognostic factor of the locally advanced rectal and rectosigmoid cancer was analyzed. PATIENTS AND METHODS One hundred patients with rectal and rectosigmoid cancer invaded beyond muscularis propria who underwent(More)
BACKGROUND/AIMS We analyzed how many lymph nodes should be examined to establish the presence or absence of lymph node metastasis, a staging factor, based on cumulative survival rate in colorectal cancer. METHODOLOGY Among those who had undergone curative resection of colorectal cancer and lymphadenectomy exceeding D2, 94 patients with Dukes' B colorectal(More)
UNLABELLED We evaluated the significance of the prognostic nutritional index(PNI)and modified Glasgow Prognostic Score(mGPS)in colorectal cancer resection. METHODS We classified 165 patients undergoing colorectal cancer excision according to PNI(>40 [n=141]and ≤40[n=24])and mGPS (A/B[n=95], C[n=44], and D [n=26]). We examined the incidence of(More)
BACKGROUND Human X-box binding protein 1 (XBP-1) is a transcription factor essential for hepatocyte growth, as well as for plasma cell differentiation. Recently, overexpression of XBP-1 has been reported in breast cancer including non-invasive carcinomas, and was suggested to play an important role in breast carcinogenesis. To investigate the involvement of(More)
BACKGROUND Stomatitis in cancer chemotherapy manifests with pronounced subjective symptoms, lowers the patient's quality of life (QOL) and may necessitate the discontinuation of chemotherapy. There have been few effective therapies established to date for chemotherapy-induced stomatitis. PATIENTS AND METHODS We used frozen allopurinol solution(More)
AIM To assess the practical efficacy of low-dose leucovorin plus 5-fluorouracil (LV/5-FU) in elderly patients with metastatic colorectal cancer. PATIENTS AND METHODS The records of 20 patients treated with LV/5-FU for unresectable metastatic disease from colorectal cancer from 1999 to 2004 were retrospectively reviewed. The patients received LV/5-FU as(More)
The expression of Fas ligand (Fas L) was investigated in sixty-seven patients with colorectal cancer for possible correlation with liver metastasis. Fas L expression was positive in 48 and negative in 19 cases. In Fas L-positive cases, 14 patients had liver metastasis including metachronous metastasis. However, only one case had liver metastasis in Fas(More)
BACKGROUND Anticancer drugs may frequently show host immunosuppression. Low-dose chemotherapy has been used for unresectable cancer as a tumor dormancy therapy, and it has been reported that the patients treated this way demonstrated favorable survival without toxicity. In this study, host immunity before and after a low-dose leucovorin plus 5-fluorouracil(More)
Phase I study of combination therapy with peptide vaccine and anti-cancer drug for colorectal cancer has been performed in our hospital. The purpose of this study was to evaluate the safety and immune response of different dose of RNF43-721 emulsified with Montanide ISA 51 in combination with S-1/CPT-11 chemotherapy. The study design was a dose escalation(More)