MOTIVATION The development of gene expression microarray technology has allowed the identification of differentially expressed genes between different clinical phenotypic classes of cancer from a large pool of candidate genes. Although many class comparisons concerned only a single phenotype, simultaneous assessment of the relationship between gene… (More)
This paper presents an EM A (electromagnetic analysis) against an RSA software on an embedded operating system (OS) and its countermeasure. First, we describe a pre-processing step to find an appropriate observation point for EM A, where the EM radiation caused by cryptographic operations can be observed in an accurate manner. We employ a specific input… (More)
BACKGROUND In randomized controlled trials (RCTs) of subjects with type 2 diabetes mellitus, mortality rates vary substantially. We sought to examine the inclusion and exclusion criteria of these RCTs to explore relationships with mortality. METHODS AND RESULTS MEDLINE database was searched from August 1980 through March 2011. Selection criterion included… (More)
Depends survival, survC1 Description Performs inference for a class of measures to compare competing risk prediction models with censored survival data. The class includes the integrated discrimination improvement index (IDI) and category-less net reclassification index (NRI).
BACKGROUND Road traffic injuries among the elderly have recently become a public health issue; therefore, we investigated the clinical characteristics of such injuries among the elderly in Japan. METHODS A retrospective study was performed using data from a medium-sized hospital emergency department. Data were extracted from medical records for one year,… (More)
Group sequential designs are often used in clinical trials to evaluate efficacy and/or futility. Many methods have been developed for different types of endpoints and scenarios. However, few of these methods convey information regarding effect sizes (e.g., treatment differences) and none uses prediction to convey information regarding potential effect size… (More)
Immunotherapies based on immune checkpoint blockade are highly effective in a subset of patients. An ongoing challenge is the identification of biomarkers that predict which patients will benefit from these therapies. Aneuploidy, also known as somatic copy number alterations (SCNAs), is widespread in cancer and is posited to drive tumorigenesis. Analyzing… (More)
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BACKGROUND Although end-of-life (EOL) care can present a substantial financial burden for the household, the influence of this burden on the intensity of care received at the EOL remains unknown. The goal of this study was to determine the association between financial hardship and intensive care in the last week of life. METHODS The Coping with Cancer… (More)