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  • Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada, Tatsuji Iga
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1999 (First Publication: 1 March 1999)
  • To evaluate the extent of drug-drug interaction concerning metabolic inhibition in the liver quantitatively, we tried to predict the plasma concentration increasing ratio of midazolam (MDZ) byExpand
  • Michiteru Ohtani, Hajime Kotaki, Yasufumi Sawada, Tatsuji Iga
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1995 (First Publication: 1 February 1995)
  • The relationships between plasma or brain concentrations and analgesic effects of both buprenorphine (BN) and an active metabolite, norbuprenorphine (NBN), were investigated in rats. MaximalExpand
  • Michiteru Ohtani, Hajime Kotaki, Kenji Nishitateno, Yasufumi Sawada, Tatsuji Iga
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1997 (First Publication: 1 April 1997)
  • The respiratory depression induced by buprenorphine and its active metabolite, norbuprenorphine (NBN), was evaluated in rats by measurement of changes in respiratory rate and arterial pCO2 levels.Expand
  • Katsuhiro Yamano, Koujirou Yamamoto, +4 authors Tatsuji Iga
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2000 (First Publication: 1 March 2000)
  • To evaluate the degree of drug-drug interaction concerning metabolic inhibition in the liver quantitatively, we tried to predict the plasma concentration increasing ratio (R) of midazolam (MDZ) byExpand
  • Katsuhiro Yamano, Koujirou Yamamoto, +4 authors Tatsuji Iga
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1999 (First Publication: 1 November 1999)
  • To predict the degree of accumulation of hepatic metabolic inhibitors in the liver from the in vitro data, we investigated the relationship between cell/medium concentration ratios (C/M ratios) inExpand
  • Katsuhiro Yamano, Koujirou Yamamoto, +6 authors Tatsuji Iga
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 2001
  • The extent of decreases in apparent hepatic clearance and intrinsic hepatic clearance of midazolam (MDZ) after intravenous administration of MDZ with concomitant oral administration of cimetidineExpand