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Histone deacetylase inhibitors such as sodium butyrate and trichostatin A induce apoptosis through an increase of the bcl-2-related protein Bad

• Hiroki Sawa, Hiromi Murakami, +8 authors Hajime Kamada
• Brain Tumor Pathology
• 2001

The effects of sodium butyrate (SB) and trichostatin A (TSA) on cell proliferation and apoptosis against human glioma T98G, U251MG, and U87MG cells were investigated. Upon exposure to either SB or… (More)

Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients

• Yoshinobu Takahashi, Hideo Nakamura, +4 authors Jun-ichi Kuratsu
• World journal of surgical oncology
• 2013

BACKGROUND To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese… (More)

Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo

• Hiroki Sawa, Hiromi Murakami, +8 authors Hajime Kamada
• Acta Neuropathologica
• 2004

We investigated the effects of FK228 on cell proliferation and apoptosis against human glioblastoma (GM) T98G, U251MG, and U87MG cells. Upon exposure to FK228, cell proliferation was inhibited, and… (More)

Histone deacetylase inhibitors such as sodium butyrate and trichostatin A inhibit vascular endothelial growth factor (VEGF) secretion from human glioblastoma cells

• Hiroki Sawa, Hiromi Murakami, +8 authors Hajime Kamada
• Brain Tumor Pathology
• 2002

We investigated the effects of histone deacetylase (HDAC) inhibitors such as sodium butyrate (SB) and trichostatin A (TSA) on the expression of vascular endothelial growth factor (VEGF) by human… (More)

Quantitative imaging of spontaneous neuromagnetic activity for assessing cerebral ischemia using sLORETA-qm

• Shinichi Sakamoto, Hiroaki Tanaka, +12 authors Hajime Kamada
• NeuroImage
• 2010

To image cerebral neural activity in ischemic areas, we proposed a novel technique to analyze spontaneous neuromagnetic fields based on standardized low-resolution brain electromagnetic tomography… (More)

Recovery of spontaneous neuromagnetic activity after extracranial–intracranial bypass in a patient with middle cerebral artery occlusion

• Shinichi Sakamoto, Wataru Ide, Ikuo Hashimoto, Hajime Kamada, Hiroaki Tanaka, Kensuke Sekihara
• Acta Neurochirurgica
• 2008

Cerebral blood flow and neuromagnetic activity were measured using 123I-iodoamphetamine-single photon emission computed tomography (IMP-SPECT) and magnetoencephalography (MEG), before and after… (More)

Prognostic value of isocitrate dehydrogenase 1, O-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients

• Yoshinobu Takahashi, Hideo Nakamura, +4 authors Jun-ichi Kuratsu
• 2013

Background: To determine the prognostic value of isocitrate dehydrogenase 1 (IDH1) mutation, O-methylguanine-DNA methyltransferase (MGMT) promoter methylation, and 1p/19q co-deletion in Japanese… (More)

Adult classical glioblastoma with a BRAF V600E mutation

• Yoshinobu Takahashi, Toshiaki Akahane, +9 authors Hajime Kamada
• World journal of surgical oncology
• 2015

The B-Raf proto-oncogene serine/threonine kinase (B-Raf) is a member of the Raf kinase family. The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma,… (More)

A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings

• Hiroshi Nishihara, Matsuyoshi Nakasato, +7 authors Shinya Tanaka
• Journal of Neuro-Oncology
• 2008

Lymphomatoid granulomatosis (LYG) in the central nervous system (CNS) is an uncommon lymphoproliferative disorder with low grade malignant potential. Here we report a case of CNS-LYG, in particular,… (More)

Hemisplenial- accompanied by internal border-zone infarction: clinical relevance of the splenium of the corpus callosum as a border-zone area between anterior and posterior cerebral arteries.

• Akihito Hashiguchi, Shigetoshi Yano, +4 authors Jun-ichi Kuratsu
• Journal of neurology, neurosurgery, and…
• 2010

DISCUSSION We described a novel SCN4A mutation that caused periodic paralysis with low or normal serum potassium level during attacks. The residue R1129 is completely conserved in voltage-dependent… (More)

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