Haiyuan Zhang

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Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.

Haiyuan Zhang, Zhaoxia Ji, +16 authors André Nel
ACS nano
2012

We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among… (More)

Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening.

Andre E Nel, Tian Xia, +4 authors Haiyuan Zhang
Accounts of chemical research
2013

The production of engineered nanomaterials (ENMs) is a scientific breakthrough in material design and the development of new consumer products. While the successful implementation of nanotechnology… (More)

Processing pathway dependence of amorphous silica nanoparticle toxicity: colloidal vs pyrolytic.

Haiyuan Zhang, Darren R. Dunphy, +15 authors C Jeffrey Brinker
Journal of the American Chemical Society
2012

We have developed structure/toxicity relationships for amorphous silica nanoparticles (NPs) synthesized through low-temperature colloidal (e.g., Stöber silica) or high-temperature pyrolysis (e.g.,… (More)

Dispersion and stability optimization of TiO2 nanoparticles in cell culture media.

Zhaoxia Ji, Xue Mei Jin, +9 authors Jeffrey I Zink
Environmental science & technology
2010

Accurate evaluation of engineered nanomaterial toxicity requires not only comprehensive physical-chemical characterization of nanomaterials as produced, but also thorough understanding of… (More)

Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential.

Xiang Wang, Zhaoxia Ji, +12 authors André Nel
Small
2014

Since more than 30% of consumer products that include engineered nanomaterials contain nano-Ag, the safety of this material is of considerable public concern. In this study, Ag nanoparticles (NPs)… (More)

Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung.

Xiang Wang, Tian Xia, +13 authors André Nel
ACS nano
2011

We developed a dispersal method for multiwalled carbon nanotubes (MWCNTs) that allows quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and in mouse lung. We… (More)

Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity.

Ruibin Li, Xiang Wang, +15 authors Tian Xia
ACS nano
2013

Functionalized carbon nanotubes (f-CNTs) are being produced in increased volume because of the ease of dispersion and maintenance of the pristine material physicochemical properties when used in… (More)

Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells.

Xiang Wang, Tian Xia, +7 authors André Nel
ACS nano
2010

In vivo studies have demonstrated that the state of dispersion of carbon nanotubes (CNTs) plays an important role in generating adverse pulmonary effects. However, little has been done to develop… (More)

Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma

Fenglian Ren, Hong Wu, +9 authors Canhua Huang
Molecular Cancer
2009

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor prognosis due to resistance to conventional chemotherapy and limited efficacy of radiotherapy. There is an… (More)

High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles.

Sijie Lin, Yan Zhao, +12 authors André Nel
ACS nano
2011

Zebrafish is an aquatic organism that can be used for high content safety screening of engineered nanomaterials (ENMs). We demonstrate, for the first time, the use of high content bright-field and… (More)

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