Haiyan Zhang

Publications25
h-index10
Citations547
Highly Influential Citations16
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • X. Bai
  • 153 Publications • 3,706 Citations
  • D. Cai
  • 120 Publications • 2,935 Citations
  • C. Zeng
  • 63 Publications • 850 Citations
  • M. Goldring
  • 322 Publications • 23,073 Citations
  • Publications
  • Influence
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2
TLDR
The results show that promoting the macrophage M1 polarisation leads to exacerbation of experimental OA partially through secretion of Rspo2 and activation of β-catenin signalling in chondrocytes.
View on BMJ
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
TLDR
It is demonstrated that dynamically controlled mTORC1 activity is crucial to coordinate chondrocyte proliferation and differentiation partially through regulating Gli2/PTHrP during endochondral bone development.
View on PubMed
Macrophages regulate the progression of osteoarthritis.
View on PubMed
Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2.
View on PubMed
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
TLDR
Metformin effectively alleviated cartilage degradation and aging through regulation of the AMPK/mTOR signaling pathways, suggesting that it could be an effective treatment for OA.
View PDF
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway
TLDR
It is found that MFG-E8 expression was downregulated both locally and systemically as OA advanced in patients with OA and in mice after destabilization of the medial meniscus surgery (DMM) to induce OA, and intra-articular injection of MFG -E8 is identified as a potential therapeutic target for OA prevention and treatment.
View on PubMed
Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice.
View on PubMed
Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis
TLDR
I inhibition of PI3K/AKT/NF‐κB axis was able to prevent aberrant bone formation and attenuate cartilage degeneration in OA mice and was found to enhance preosteoblast proliferation, differentiation, and expression of MMP‐13 by activating NF‐κBs pathway.
View on Wiley
Positive‐Feedback Regulation of Subchondral H‐Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice
TLDR
A positive‐feedback regulation of H‐type vessel formation in subchondral bone by articular chondrocyte nutrient‐sensing mTORC1 signaling is essential for the pathogenesis and progression of OA.
View on Wiley
Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
TLDR
It is demonstrated that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA, but can induce aberrant sub chondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.
View on Springer
...
...