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Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in pancreatic ductal adenocarcinoma (PDAC), serving a critical role in tumor initiation. Here, an inducible Kras(G12D)-driven PDAC mouse model establishes that advanced PDAC remains(More)
Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that is driven by aberrant signaling of growth factor receptors, particularly the epidermal growth factor receptor (EGFR). EGFR signaling is tightly regulated by receptor endocytosis and lysosome-mediated degradation, although the molecular mechanisms governing such regulation,(More)
This is the first report of a novel protein from Clonorchis sinensis (C. sinensis), serine/threonine protein kinase 17A (CsSTK17A), which belongs to a member of the death-associated protein kinase (DAPK) family known to regulate diverse biological processes. The full-length sequence encoding CsSTK17A was isolated from C. sinensis adult cDNA plasmid library.(More)
Compared with traditional teaching, case study method of teaching is an interactive learning approach, which changes the role of students from passive participants to active learners. Modern education has been expedited by digital tools, such as Web-based learning environment. How to align the advantage of network environment with the case study teaching(More)
In todaypsilas dynamic business environment, the competition pattern is essentially the competition of one supply chain with another rather than single enterprise. Thus, collaborations in enterprises emerge as the times require. Along with the benefits brought by these kinds of collaborations, the risks arising in the cooperation process produce extra costs(More)
The search for novel superhard materials with special structures and improved thermal stability and hardness remains considerably experimental and theoretical challenges. Recent reports proposed that higher carbon content in ternary B2CxO compounds, which are isoelectronic with diamond, would lead to increased strength and hardness. This notion was derived(More)
UNLABELLED TBK1 (TANK-binding kinase 1) is a noncanonical IκB protein kinase that phosphorylates and activates downstream targets such as IRF3 and c-Rel and, mediates NF-κB activation in cancer. Previous reports demonstrated synthetic lethality of TBK1 with mutant KRAS in non-small cell lung cancer (NSCLC); thus, TBK1 could be a novel target for treatment(More)