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The immunogenicity and protective efficacy of a recombinant subunit West Nile virus (WNV) vaccine was evaluated in rhesus macaques (Macaca mulatta). The vaccine consisted of a recombinant envelope (E) protein truncated at the C-terminal end, resulting in a polypeptide containing 80% of the N-terminal amino acids of the native WNV protein (WN-80E), mixed(More)
Neurological complications such as inflammation, failure of the blood-brain barrier (BBB), and neuronal death contribute to the mortality and morbidity associated with WNV-induced meningitis. Compromised BBB indicates the ability of the virus to gain entry into the CNS via the BBB, however, the underlying mechanisms, and the specific cell types associated(More)
The blood-brain barrier (BBB) is a major obstacle to gene therapy for genetic and infectious diseases in the central nervous system (CNS). At present, invasive techniques such as direct intracerebral injection of viral vector are necessary for clinical applications. Our laboratory is interested in developing a noninvasive cell-based gene delivery system for(More)
—Cognitive radio (CR) has been proposed as a promising solution to improve connectivity, self-adaptability, and efficiency of spectrum usage. When used in video applications, user-perceived video quality experienced by secondary users is a very important performance metric to evaluate the effectiveness of CR technologies. However, most of the current(More)
Remote human motion tracking and gait analysis over wireless networks can be used for various e-healthcare systems for fast medical prognosis and diagnosis. However, most existing gait tracking systems rely on expensive equipment and take lengthy processes to collect gait data in a dedicated biomechanical environment, limiting their accessibility to small(More)
—Most existing works on routing for video transmission over multihop wireless networks only focus on how to satisfy the network-oriented quality-of-service (QoS), such as through-put, delay, and packet loss rate rather than application-oriented QoS such as the user-perceived video quality. Although there are some research efforts which use(More)
2467 in the entire network. Since a minimum load imbalance does not necessarily lead to a minimum total service load, this optimization goal requires some compromise between the two minimization criteria. Reducing the number of mobile sensors for coverage tasks, " in Proc. A distributed actor-critic algorithm and applications to mobile sensor network(More)