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Particle swarm optimization (PSO) is originally developed as an unconstrained optimization technique, therefore lacks an explicitmechanism for handling constraints.When solving constrained optimization problems (COPs) with PSO, the existing research mainly focuses on how to handle constraints, and the impact of constraints on the inherent search mechanism(More)
In the human disorder multiple sclerosis (MS) and in the model experimental autoimmune encephalomyelitis (EAE), macrophages predominate in demyelinated areas and their numbers correlate to tissue damage. Macrophages may be derived from infiltrating monocytes or resident microglia, yet are indistinguishable by light microscopy and surface phenotype. It is(More)
This paper firstly presents a novel constraint-handling technique , called dynamicobjective method (DOM), based on the search mechanism of the particles of particle swarm optimization (PSO). DOM converts the constrained optimization problem into a bi-objective optimization problem, and then enables each particle to dynamically adjust its objectives(More)
CC chemokine ligand 2 (CCL2), a ligand of CC chemokine receptor 2 (CCR2), is essential to mount an adequate inflammatory response to repair acute skeletal muscle injury. We studied the mechanisms by which CCL2 regulates muscle inflammation and regeneration. Mobilization of monocytes/macrophages (MOs/MPs) but not lymphocytes or neutrophils was impaired from(More)
CC chemokine receptor 2 (CCR2) is essential to acute skeletal muscle injury repair. We studied the subpopulation of inflammatory cells recruited via CCR2 signaling and their cellular functions with respect to muscle regeneration. Mobilization of monocytes/macrophages (MOs/MPs), but not lymphocytes or neutrophils, was impaired from bone marrow to blood and(More)
Soft magnetic composite (SMC) materials are especially suitable for developing electrical machines with complex structure and three-dimensional (3-D) magnetic flux path. In these SMC machines, the magnetic field is in general 3-D and rotational, so the mechanism and calculation of core loss may be quite different from that in traditional electrical machines(More)
Muscle fibrosis is a prominent pathological feature that directly causes muscle dysfunction in Duchenne muscular dystrophy (DMD). The DMD mouse models, mdx mice and mdx mice with haploinsufficiency of the utrophin gene (mdx/utrn(+/-) ), display progressive diaphragm fibrosis. We performed unrestrained whole-body plethysmography (WBP) in mdx and(More)
Continuing with a set of enabling techniques for the optimal coordination of plug-in electric vehicles (PEVs) in Part I, we present a case study in this paper using techniques based on the data collected in the Beijing-Tianjin-Tangshan Region (BTTR) China to discover optimal PEV coordination strategies and assess the attractiveness of these strategies. In(More)
Web-page recommendation plays an important role in intelligent Web systems. Useful knowledge discovery from Web usage data and satisfactory knowledge representation for effective Web-page recommendations are crucial and challenging. This paper proposes a novel method to efficiently provide better Web-page recommendation through semantic-enhancement by(More)
In addition to effects on tumor cell proliferation and apoptosis, microtubule-binding agents are potent inhibitors of angiogenesis. The cancer chemotherapeutic drug Taxotere (docetaxel) inhibited vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) migration in vitro at concentrations substantially lower than(More)