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A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction of 8-iodo-5,7-dimethoxyflavone and alkyl/areneboronic acids as a key reaction. Among the analogs(More)
A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited(More)
RB-RBAC (Rule-Based RBAC) provides the mechanism to dynamically assign users to roles based on a finite set of authorization rules defined by the enterprise's security policy. The RB-RBAC family introduces negative authorization, represented by negative roles, which may bring conflict, and conflict detection and resolution become an import work in RB-RBAC(More)
Public-key infrastructures (PKIs) are essential for providing electronic payment security services such as authentication and privacy in open networks like Internet. The purpose of this paper is to propose a description logic-based approach to modeling and reasoning about PKI trust domain. In the formalism, concept model is used to formalize PKI entities(More)
We previously reported that oroxylin A, a γ-aminobutyric acid A (GABAA) receptor antagonist, ameliorates drugs-induced memory impairments. We synthesized several oroxylin A derivatives in efforts to find a substance that has pro-cognitive effects as well as improves sensorimotor gating. The aim of the present study is to investigate the effect of a novel(More)
Ontologies undergo changes for reasons such as changes in knowledge , meeting varying application requirements. Thus, for different versions of a considered ontology, it is important to clarify the difference between them. The difference above refers to the logical difference, not syntactic one. Examples of the logical difference include the difference in(More)