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The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we(More)
BACKGROUND Functional connectivity in default mode network (DMN) may be changed in Alzheimer's disease (AD) patients and related risk populations, such as amnestic mild cognitive impairment (aMCI) patients and APOE ε4 carriers. Exploring DMN changes and related behavioral performance of APOE ε4 population might provide valuable evidence for better(More)
The single nucleotide polymorphism (SNP) that leads to a valine-to-methionine substitution at codon 66 (Val66Met) in BDNF is correlated with differences in cognitive and memory functions, as well as with several neurological and psychiatric disorders. MRI studies have already shown that this genetic variant contributes to changes in cortical thickness and(More)
Nowadays with the readily accessibility of online social networks (OSNs), people are facilitated to share interesting information with friends through OSNs. Undoubtedly these sharing activities make our life more fantastic. However, meanwhile one challenge we have to face is information overload that we do not have enough time to review all of the content(More)
BACKGROUND Multiple sequence alignment (MSA) is one of the most important research contents in bioinformatics. A number of MSA programs have emerged. The accuracy of MSA programs highly depends on the parameters setting, mainly including gap open penalties (GOP), gap extension penalties (GEP) and substitution matrix (SM). This research tries to obtain the(More)
In this paper, firstly, an adaptive Dense-SIFT feature extraction method is proposed, which can adaptively adjust the size of local window using the edge information of image. Next, a large scale image retrieval method is proposed. The adaptive Dense-SIFT features are extracted from the database images. Bag of Word (BoW) model is then adopted to create the(More)