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Phenylketonuria (PKU) is an inherited autosomal recessive disorder of phenylalanine metabolism, mainly caused by a deficiency of phenylalanine hydroxylase (PAH). The incidence of various PAH mutations differs among race and ethnicity. Here we report a spectrum of PAH mutations complied from 796 PKU patients from mainland China. The all 13 exons and adjacent(More)
Argonaute (AGO) proteins play a key role in regulation of gene expression through small RNA-directed RNA cleavage and translational repression, and are essential for multiple developmental processes. In the present study, 17 AGO genes of maize (Zea mays L., ZmAGOs) were identified using a Hidden Markov Model and validated by rapid amplification of cDNA ends(More)
BACKGROUND A growing body of research has suggested that tetrahydrobiopterin (BH4) responsive phenotype can be predicted by the phenylalanine hydroxylase (PAH) genotype in patients with phenylketonuria (PKU), but data concerning the association between genotype and BH4 responsiveness are scarce in China. METHODS A total of 165 PKU patients from China who(More)
A T-S Fuzzy neural network (FNN) is a combination of a neural network and a T-S fuzzy system. It not only can mimic the human brain logic thinking, but also has the ability of artificial neural networks, thus it is used widely in recognition. The music signal data is used in simulation. To gain a better recognition result, the error recognition data of(More)
Nowadays, Image classification method has been widely researched in the world. In this paper, we prepare four building categories for database. Firstly we use the Gabor filter for image processing to extract the image features, and then divide the images to different subregions for histogram-based Gabor features. At last, for image classification, Support(More)
Neural stem/progenitor cells transit from fibroblast growth factor-responsive to epidermal growth factor (EGF)-responsive stem cells in the subventricular zone (SVZ). Here, we provide evidences that Pax6 plays a crucial role in the regulation of the EGF-responsive stem cell pool of the SVZ. Using Pax6 homozygous mutant mice (E18.5d), we found that the(More)
The yield of maize grain is a highly complex quantitative trait that is controlled by multiple quantitative trait loci (QTLs) with small effects, and is frequently influenced by multiple genetic and environmental factors. Thus, it is challenging to clone a QTL for grain yield in the maize genome. Previously, we identified a major QTL, qKNPR6, for kernel(More)
Decision tree is an important tool in decision analysis. In this paper, we propose the optimized ID3 Algorithm and three principles for pruning algorithm in different cases. Based on the Scilab platform, the application in a personal credit issue performs better than the traditional method. Besides, the difference between the decision tree and rough set is(More)
OBJECTIVE To compare the proteome difference between multiple myeloma cell line U266 cells treated and untreated with PS-341, to investigate the potential drug targets, and to provide theoretical evidence for clinical therapy of multiple myeloma. METHODS Two-dimensional gel electrophoresis (2-DE) was performed to separate proteins from treated and(More)
Alternative splicing (AS) is an important regulatory mechanism that greatly contributes to eukaryotic transcriptome diversity. A substantial amount of evidence has demonstrated that AS complexity is relevant to eukaryotic evolution, development, adaptation, and complexity. In this study, six teosinte and ten maize transcriptomes were sequenced to analyze AS(More)