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The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats.
It is concluded that CAMFs exerted apparent antidiabetic effects and demonstrated as a valuable candidate nutraceutical for insulin-resistant type 2 diabetes and its associated complications such as dyslipidemia, oxidative stress, and inflammation.
Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla
Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values comparable with the reference standard, chloroquine.
Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and
Abstract Pseuduvaria macrophylla (Family: Annonaceae) is commonly used as medicinal plant in Malaysia. A recent study with the Pseuduvaria species showed antioxidant and antidiabetic effects. This
Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark
PMm was found to downregulate the levels of oxidative stress and pro-inflammatory cytokines in type 2 diabetic rats by alleviating hyperglycemia and may be developed as an antidiabetic agent for the treatment of type 2 diabetes-associated conditions.
A Brief Review on Bioactive Compounds from Pseuduvaria Species
The Pseuduvaria species belong to the family Annonaceae which is rich in bioactive compounds. They are commonly found in Malaysia, Thailand, Burma and Indonesia and in the northeastern part of
Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models
The methanol extract from the leaves and the stems of Enicosanthellum pulchrum showed notable gastroprotective potential against ethanol, and exhibited down- regulation of Bax and up-regulation of Hsp70 proteins.
Therapeutic Potential of Plant Species Derived from Some Annonaceae Genus
Four therapeutic potential of many species derived from some Annonaceae genus will be discussed based on previous published research for future testing usage.
Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats.
Interestingly, protective nature of the extract was further revealed by the immunohistochemical study result which displayed upregulation in the insulin and renal Bcl-2 expression, the anti apoptosis protein, thus warrants further investigation on its major compounds with in depth mechanistic studies at molecular level.
Pseuduvarines A and B, two new cytotoxic dioxoaporphine alkaloids from Pseuduvaria rugosa.
Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 and were elucidated by combination of 2D-NMR spectroscopic analysis.