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Proper bipolar attachment of sister kinetochores to the mitotic spindle is critical for accurate chromosome segregation in mitosis. Here we show an essential role of the formin mDia3 in achieving metaphase chromosome alignment. This function is independent of mDia3 actin nucleation activity, but is attributable to EB1-binding by mDia3. Furthermore, the(More)
FPGA-based computing boards are frequently used as hardware accelerators for image processing algorithms based on sliding window operations (SWOs). SWOs are both computationally intensive and data intensive and benefit from hardware acceleration with FPGAs, especially for delay sensitive applications. The current design process requires that, for each(More)
We demonstrate the use of a "smart camera " to accelerate two very different image processing applications. The smart camera consists of a high quality video camera and frame grabber connected directly to an FPGA processing board. The advantages of this setup include minimizing the movement of large datasets and minimizing the latency by starting to process(More)
Digital Particle Image Velocimetry (PIV) is well established as a fluid dynamics measurement tool, being capable of non-intrusively and concurrently measuring a distributed velocity filed. Yet the intensive computational requirements of PIV limit its usage almost exclusively to off-line processing, analysis and modelling. This paper proposes hardware(More)
Most image processing applications are not only computationally intensive, but also data intensive. Reconfigurable hardware boards provide a convenient and flexible solution to speed up these algorithms. To get a high performance design without going through the time-consuming hardware design process for each different algorithm, we present a simple design(More)
Due to increases in design complexity, routing a reset signal to all registers is becoming more difficult. One way to solve this problem is to reset only certain registers and rely on a software initialization sequence to reset other registers. This approach, however, may allow unknown values (also called X-values) in uninitialized registers to leak to(More)
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