Hainan Wang

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UNLABELLED WHAT IS ALREADY KNOWN ABOUT THE SUBJECT: * Concomitant use of different drugs may yield excessive risk for adverse drug reactions and it is a challenging task to do surveillance on the safety profile of the interaction between different drugs. * Currently, several methods are used by pharmacoepidemiologists and statisticians to detect possible(More)
PURPOSE We developed a computerized system for signal detection in spontaneous reporting system (SRS) of Shanghai. Data acquisition, data mining could be carried out automatically and the process of data preprocessing and cleaning could be facilitated. This system was expected to detect signals from SRS after drug licensing with minimum patient exposure. (More)
PURPOSE To give an overview of the current status including problems and efforts about pharmacovigilance in Traditional Chinese Medicine (TCM) safety surveillance. METHODS It is based on literature review and publicly available data in China. RESULTS TCM led to several adverse drug reactions (ADRs) during the past few years and pharmacovigilance about(More)
OBJECTIVE Epididymal protease inhibitor (Eppin) was located on the surface of spermatozoa and modulates the liquefaction of human semen. Here, we identify the correlative protein partner of Eppin to explore the molecular mechanism of liquefaction of human semen. METHODS (1) Human seminal vesicle proteins were transferred on the membrane by Western(More)
Conclusions: The data suggest that co-incubation with anti-VDAC antibody reduces sperm motility through inhibition of Ca transmembrane flow. In this way, VDAC participates in the modulation of human sperm motility through mediating Ca transmembrane transport. Abstract: Meta-analysis Polymorphism Studies of the relationship between male infertility and(More)
and GSTT1 null genotype in cancer risks. Methods: A meta-analysis based on 506 case-control studies was performed. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. Results: The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk incancer respectively).(More)
Conclusions: The data suggest that co-incubation with anti-VDAC antibody reduces sperm motility through inhibition of Ca transmembrane flow. In this way, VDAC participates in the modulation of human sperm motility through mediating Ca transmembrane transport. Abstract: Meta-analysis Polymorphism Studies of the relationship between male infertility and(More)
BACKGROUND Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible(More)
Nuclear auto-antigenic sperm protein (NASP), initially described as a highly auto-immunogenic testis and sperm-specific protein, is a histone chaperone that is proved to present in all dividing cells. NASP has two splice variants: testicular NASP (tNASP) and somatic form of NASP (sNASP). Only cancer, germ, transformed, and embryonic cells have a high level(More)
Galangin, a flavonoid extracted from the root of the Alpinia officinarum Hence, has been shown to have anticancer properties against several types of cancer cells. However, the influence of galangin on human renal cancer cells remains to be elucidated. In the present study, proliferation of 786‑0 and Caki‑1 cells was suppressed following exposure to various(More)