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OBJECTIVE Epididymal protease inhibitor (Eppin) was located on the surface of spermatozoa and modulates the liquefaction of human semen. Here, we identify the correlative protein partner of Eppin to explore the molecular mechanism of liquefaction of human semen. METHODS (1) Human seminal vesicle proteins were transferred on the membrane by Western(More)
Conclusions: The data suggest that co-incubation with anti-VDAC antibody reduces sperm motility through inhibition of Ca transmembrane flow. In this way, VDAC participates in the modulation of human sperm motility through mediating Ca transmembrane transport. Abstract: Meta-analysis Polymorphism Studies of the relationship between male infertility and(More)
and GSTT1 null genotype in cancer risks. Methods: A meta-analysis based on 506 case-control studies was performed. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. Results: The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk incancer respectively).(More)
Conclusions: The data suggest that co-incubation with anti-VDAC antibody reduces sperm motility through inhibition of Ca transmembrane flow. In this way, VDAC participates in the modulation of human sperm motility through mediating Ca transmembrane transport. Abstract: Meta-analysis Polymorphism Studies of the relationship between male infertility and(More)
BACKGROUND Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible(More)
This study aimed to explore the association between the methylation status of the VDAC2 gene promoter region and idiopathic asthenospermia (IAS). Twenty-five IAS patients and 27 fertile normozoospermia (NZ) were involved. GC-2spd cells were treated with different concentrations of 5-aza-2'-deoxycytidine (5-Aza-CdR) for 24 h and 48 h. qRT-PCR was conducted(More)
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