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The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is(More)
The human genome is diploid, and knowledge of the variants on each chromosome is important for the interpretation of genomic information. Here we report the assembly of a haplotype-resolved diploid genome without using a reference genome. Our pipeline relies on fosmid pooling together with whole-genome shotgun strategies, based solely on next-generation(More)
Mastoparans are a family of small peptides identified from the venom of hymenopteroid insects. Although they have been characterized as early as 1979, and so far are recognized as a leading biomolecule in potential drug therapy, their precursors, mastoparanogen, have still not been determined. In this paper, several mastoparans from the venom of the wasp(More)
Ensuring the <i>quality of service</i> (QoS) for latency-sensitive applications while allowing co-locations of multiple applications on servers is critical for improving server utilization and reducing cost in modern warehouse-scale computers (WSCs). Recent work relies on static profiling to precisely predict the QoS degradation that results from(More)
BACKGROUND Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes. No cathelicidins from other non-mammalian vertebrates have been reported. PRINCIPAL FINDINGS In this work, a(More)
A novel antimicrobial peptide named as ixosin was isolated from the salivary glands of the hard tick, Ixodes sinensis, by gel filtration, ion exchange chromatography and reverse-phase high-performance liquid chromatography (RP-HPLC). Its amino acid sequence was determined as GLHKVMREVLGYERNSYKKFFLR by Edman degradation and its molecular weight was 2870.5(More)
While investigating the innate defense of brackish water-living amphibian and its comparison with freshwater-living amphibians, two novel 12-residue antimicrobial peptides were purified from the skin secretions of the crab-eating frog, Fejervarya cancrivora which typically inhabits brackish water of mangrove forests of Southeast Asia. These two(More)
Large-scale data-intensive cloud computing with the MapReduce framework is becoming pervasive for the core business of many academic, government, and industrial organizations. Hadoop, a state-of-the-art open source project, is by far the most successful realization of MapReduce framework. While MapReduce is easy- to-use, efficient and reliable for(More)
— ALLIANCES (ALLow Improved Access in the Network via Cooperation and Energy Savings) is a recently proposed cooperative random access protocol for wireless networks that capitalizes on the broadcast nature of the wireless channel. When a collision occurs, a set of nodes form an alliance and retransmit the collision signal that they heard. The initial(More)
Cathelicidins comprise a family of antimicrobial peptides (AMPs) sharing a highly conserved cathelin domain, and play a central role in the innate defense against infection in most of vertebrates. But so far it has not yet been found in amphibians although a large number of other groups of AMPs have been identified. In the current work, the first amphibian(More)