Hailong Wu

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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

Shuomin Zhu, Hailong Wu, Fangting Wu, Daotai Nie, Shijie Sheng, Yin-yuan Mo
Cell Research
2008

MicroRNAs (miRNAs) are a class of naturally occurring small non-coding RNAs that target protein-coding mRNAs at the post-transcriptional level. Our previous studies suggest that mir-21 functions as… (More)

MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

Shuomin Zhu, Mufti Si, Hailong Wu, Yin-yuan Mo
The Journal of biological chemistry
2007

MicroRNAs are small noncoding RNA molecules that control expression of target genes. Our previous studies show that mir-21 is overexpressed in tumor tissues compared with the matched normal tissues.… (More)

p53 represses c-Myc through induction of the tumor suppressor miR-145.

Mohit Sachdeva, Shoumin Zhu, +6 authors Yin-yuan Mo
Proceedings of the National Academy of Sciences…
2009

The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may… (More)

Suppression of cell growth and invasion by miR-205 in breast cancer

Hailong Wu, Shoumin Zhu, Yin-yuan Mo
Cell Research
2009

MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs, which are capable of silencing gene expression at the post-transcriptional level. In this study, we report that miR-205 is significantly… (More)

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

Ping Zhang, Anju Singh, +6 authors Shyam Biswal
Molecular cancer therapeutics
2010

Loss-of-function mutations in the nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor Kelch-like ECH-associated protein 1 (Keap1) result in increased Nrf2 activity in non-small cell lung… (More)

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.

Beverly A. Rothermel, Rick B. Vega, Jianyi Yang, Hailong Wu, Rhonda Bassel-Duby, R. Sanders Williams
The Journal of biological chemistry
2000

Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a… (More)

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.

Anju Dadhwal Singh, Hailong Wu, Ping Zhang, Christine Happel, Jinfang Ma, Shyam Biswal
Molecular cancer therapeutics
2010

ATP-binding cassette, subfamily G, member 2 (ABCG2) is expressed in both normal and cancer cells and plays a crucial role in side population (SP) formation and efflux of xenobiotics and drugs. Nrf2,… (More)

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.

Ming-Jiang Xu, Dechun Feng, +10 authors Bin Gao
Hepatology
2015

UNLABELLED Lipocalin-2 (LCN2) was originally isolated from human neutrophils and termed neutrophil gelatinase-associated lipocalin (NGAL). However, the functions of LCN2 and the cell types that are… (More)

Sp1 and CREB mediate gastrin-dependent regulation of chromogranin A promoter activity in gastric carcinoma cells.

Michael Hoecker, Raktima Raychowdhury, +5 authors Timothy C Wang
The Journal of biological chemistry
1998

Chromogranin A (CgA) is a multifunctional acidic protein that in the stomach is expressed predominantly in enterochromaffin-like cells (ECL cells) where it is regulated by gastrin. In order to… (More)

Regulation of bcl-2 expression by Ubc9.

Zhaohui Lu, Hailong Wu, Yin-yuan Mo
Experimental cell research
2006

Posttranslational modifications mediated by ubiquitin-like proteins have been implicated in regulating a variety of cellular pathways. Although small ubiquitin-like modifier (SUMO) is a new member of… (More)

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