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BACKGROUND A successful gene delivery system needs to breakthrough several barriers to allow efficient transgenic expression. In the present study, successive targeting liposomes (STL) were constructed by integrating various targeting groups into a nanoparticle to address this issue. METHODS Polyethylenimine (PEI) 1800-triamcinolone acetonide (TA) with(More)
BACKGROUND Multidrug resistance (MDR) mediated by the overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), remains one of the major obstacles to effective cancer chemotherapy. In this study, lipid/particle assemblies named LipoParticles (LNPs), consisting of a dimethyldidodecylammonium bromide(More)
Tracking control laws are developed for a rigid spacecraft using both thrusters and momentum wheels. The model studied comprises a rigid body with external thrusters and with rigid axisymmetric wheels controlled by axial torques. Modified Rodrigues parameters (MRPs) are used to describe the kinematics. The thruster torques and the axial motor torques are(More)
A control law for an Integrated Power/Attitude Control System (IPACS) for a satellite is presented in this paper. Four or more energy/momentum wheels in an arbitrary non-coplanar configuration and a set of three thrusters are used to implement the torque inputs. The energy/momentum wheels are used as attitude control actuators, as well as an energy storage(More)
With the potential uses of photothermal therapy (PTT) in cancer treatment with excellent efficacy, and the growing concerns about the nanotoxicity of hyperthermia agents such as carbon nanotubes and gold-based nanomaterials, the importance of searching for a biocompatible hyperthermia agent cannot be emphasized too much. In this work, a novel promising(More)
BACKGROUND Nuclear membrane is one of the main barriers in polymer mediated intracellular gene delivery. To improve the transgenic activity and safety of nonviral vector, triamcinolone acetonide (TA) as a nuclear localization signal was conjugated with different molecular weight polyethylenimine (PEI). METHODS Different molecular weight PEI [600, 1800,(More)
A control law for an Integrated Power/Attitude Control System (IPACS) for a satellite is presented in this paper. Four non-coplanar momentum wheels in a special configuration, and a set of three thrusters are used to implement the torque inputs. The momentum wheels are used as attitude control actuators, as well as an energy storage mechanism, providing(More)
This paper develops a robust divided difference filtering approach based on the concept of Desensitized Kalman Filtering. The filters are formulated using a minimum variance cost function, augmented with a penalty function consisting of a weighted norm of the state sensitivities. Solutions are provided for first and second-order Divided Difference Filters.(More)
This paper studies the scheduling of servicing multiple satellites in a circular orbit. Specifically, one servicing spacecraft (SSc) is considered to be initially on the circular orbit of the satellites to be serviced. The SSc then rendezvous with each satellite of the constellation and services it until all satellites are visited. The total time is assumed(More)