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BACKGROUND Multidrug resistance (MDR) mediated by the overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), remains one of the major obstacles to effective cancer chemotherapy. In this study, lipid/particle assemblies named LipoParticles (LNPs), consisting of a dimethyldidodecylammonium bromide(More)
— Consideration is given to attitude control associated with capturing a free-flying asteroid using an axisymmetric spacecraft. Asymptotically stable controllers are designed to align the spacecraft axis of symmetry with a line of descent that is fixed in the asteroid, and to eliminate all relative angular velocity before capture takes place. An analytical(More)
Identification of small-molecule compounds that can bind specifically and stably to protein targets of biological interest is a challenge task in structure-based drug design. Traditionally, several fast approaches such as empirical scoring functions and free energy analysis have been widely used to fulfill for this purpose. In the current study, we raised(More)
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