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A number of clinical trials have shown that a high loading dose of atorvastatin (Ator) within 24h before percutaneous coronary intervention (PCI) exerts protective effects on the cardiovascular system. However, the potential mechanisms regarding this rapid benefit of Ator remain elusive. Our study introduced three different ischaemia/reperfusion (I/R)(More)
—Patch-based sparse representation and low-rank approximation for image processing attract much attention in recent years. The minimization of the matrix rank coupled with the Frobenius norm data fidelity can be solved by the hard thresholding filter with principle component analysis (PCA) or singular value decomposition (SVD). Based on this idea, we(More)
Statins are widely used as hypolipidemic drugs, and have beneficial effects in reducing cardiovascular events. In addition, recent studies on the pleiotropic effects of statins (i.e., simvastatin) reveal that these drugs have many additional anti-atherogenic effects, including antiplatelet activity. The mechanisms may be partly related to activation of(More)
OBJECTIVE Culturing aortic valve interstitial cells is a useful way to investigate the physiology and pathology of the aortic valve at the cellular level. The culture methods of the cells have been established in many species. However, the previous methods need some improvements. METHODS We evaluated various techniques with regard to the isolation of(More)
BACKGROUND Arterial calcification is a major event in the progression of atherosclerosis. It is reported that statins exhibit various protective effects against vascular smooth muscle cell (VSMC) inflammation and proliferation in cardiovascular remodeling. Although statins counteract atherosclerosis, the molecular mechanisms of statins on the calcium(More)
BACKGROUND The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardiovascular disease remains(More)
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt età la diffusion(More)
AIMS Vascular smooth muscle cells (VSMCs) played an important role in vascular remodeling. dl-3-n-butylphthalide (NBP) was extracted as a pure component from seeds of Apium graveolens Linn (Chinese celery) for protecting neurons activity, but the role of NBP on VSMCs was not clearly clarified. MAIN METHODS Cell proliferation was measured by MTS and flow(More)
We first establish a law of large numbers and a convergence theorem in distribution to show the rate of convergence of the non-local means filter for removing Gaussian noise. We then introduce the notion of degree of similarity to measure the role of similarity for the non-local means filter. Based on the convergence theorems, we propose a patch-based(More)
Objective Atorvastatin reduces the incidence of cardiovascular events. However, the effects of atorvastatin on platelet aggregation are unknown. Methods Blood samples were obtained from 126 healthy volunteers. Prepared isolated platelet suspensions were adjusted with saline to three different concentrations of 100 × 109, 300 × 109, and 600 × 109(More)