Haijiang Lin

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Polyploids require Bik1 for kinetochore–microtubule attachment

Haijiang Lin, Pedro de Carvalho, +4 authors David S Pellman
The Journal of cell biology
2001

The attachment of kinetochores to spindle microtubules (MTs) is essential for maintaining constant ploidy in eukaryotic cells. Here, biochemical and imaging data is presented demonstrating that the… (More)

Mitochondrial DNA damage and its potential role in retinal degeneration

Stuart Gordon Jarrett, Haijiang Lin, Bernard F. Godley, Michael Boulton
Progress in Retinal and Eye Research
2008

Mitochondria are central to retinal cell function and survival. There is increasing evidence to support an association between mitochondrial dysfunction and a number of retinal pathologies including… (More)

Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells.

Haijiang Lin, Jinqiao Qian, +4 authors Yingjiang Ye
Investigative ophthalmology & visual science
2011

PURPOSE Micro(mi)RNAs negatively regulate a wide variety of genes through degradation or posttranslational inhibition of their target genes. The purpose of this study was to investigate the role of… (More)

Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.

Haijiang Lin, Jill E. Hutchcroft, Christopher E Andoniou, Malek Kamoun, Hamid Band, Barbara E Bierer
The Journal of biological chemistry
1998

Human CD2 is a 50-55-kDa cell surface receptor specifically expressed on the surface of T lymphocytes and NK cells. Stimulation of human peripheral blood T cells with mitogenic pairs of anti-CD2… (More)

Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration.

Haijiang Lin, Haifeng Xu, +5 authors Bernard F. Godley
Investigative ophthalmology & visual science
2011

PURPOSE Mitochondrial DNA (mtDNA) damage may be associated with age-related diseases, such as age-related macular degeneration (AMD). The present study was designed to test whether the frequency of… (More)

Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.

Yuzhu Hou, Haijiang Lin, +10 authors Yong Zhao
Arthritis and rheumatism
2013

OBJECTIVE The protease HTRA-1 is closely associated with rheumatoid arthritis (RA). The molecular mechanisms that control HTRA-1 expression are currently unknown. This study was undertaken to… (More)

Mitochondrial DNA has a pro-inflammatory role in AMD.

Bernard Dib, Haijiang Lin, +5 authors Demetrios G Vavvas
Biochimica et biophysica acta
2015

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly of industrialized nations, and there is increasing evidence to support a role for chronic… (More)

The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.

Yuzhu Hou, Haijiang Lin, +11 authors Yong Zhao
Journal of immunology
2014

The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need… (More)

Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells

Bo Tian, Ahmad Al-Moujahed, +6 authors Demetrios G Vavvas
Scientific Reports
2017

Phagocytosis of daily shed photoreceptor outer segments is an important function of the retinal pigment epithelium (RPE) and it is essential for retinal homeostasis. RPE dysfunction, especially… (More)

miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells

Bo Tian, Daniel E Maidana, +5 authors Haijiang Lin
PloS one
2016

Oxidative stress has been shown to contribute to the development of age-related macular degeneration (AMD). MicroRNAs (miRNA) are small non-coding RNA molecules that function in RNA silencing and… (More)

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