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Due to the uniform cyto-architecture of the cerebellar cortex, its overall physiological characteristics have traditionally been considered to be homogeneous. In this study, we show in awake mice at rest that spiking activity of Purkinje cells, the sole output cells of the cerebellar cortex, differs between cerebellar modules and correlates with their(More)
BACKGROUND There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter < or = 2.5 microm (PM(2.5))], which derives primarily from combustion processes, can result in increased mortality and morbidity. There is less certainty as to the contribution of coarse PM (PM(2.5-10)), which(More)
OBJECTIVE To add to the evidence on comparative long-term effects of insulin analog glargine versus human NPH insulin on the risk for cancer. RESEARCH DESIGN AND METHODS We identified cohorts of initiators of glargine and human NPH without an insulin prescription during the prior 19 months among patients covered by the Inovalon Medical Outcomes Research(More)
This study examined the associations among sleep duration, insomnia, and behavioral problems in a sample of 1359 Chinese adolescents. Participants completed a self-administrated questionnaire that included questions on sleep duration and insomnia symptoms and the Youth Self-Report of Child Behavior Checklist. It was found that adolescents who complained of(More)
Familial Alzheimer's disease (FAD) is characterized by autosomal dominant heritability and early disease onset. Mutations in the gene encoding presenilin-1 (PS1) are found in approximately 80% of cases of FAD, with some of these patients presenting cerebellar damage with amyloid plaques and ataxia with unclear pathophysiology. A Colombian kindred carrying(More)
—In this paper, risk-aware cooperative spectrum access schemes for cognitive radio networks (CRNs) with multiple channels are proposed, whereby multiple primary users (PUs) operating over different channels choose trustworthy secondary users (SUs) as relays to improve throughput, and in return SUs gain transmission opportunities. To study the multi-channel(More)
—The recent advances in wireless communication techniques have made it possible for fast-moving vehicles to download data from the roadside communications infrastructure [e.g., IEEE 802.11b Access Point (AP)], namely, Drive-thru Internet. However, due to the high mobility, harsh, and intermittent wireless channels, the data download volume of individual(More)
This paper studies estimation of partially linear hazard regression models with varying coefficients for multivariate survival data. A profile pseudo-partial likelihood estimation method is proposed. The estimation of the parameters of the linear part is accomplished via maximization of the profile pseudo-partial likelihood, while the varying-coefficient(More)
BACKGROUND Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters nasal inflammatory and antiviral(More)