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Ibrutinib, which irreversibly inhibits Bruton tyrosine kinase, was evaluated for antitumor activity in a panel of non-small cell lung cancer (NSCLC) cell lines and found to selectively inhibit growth of NSCLC cells carrying mutations in the epidermal growth factor receptor (EGFR) gene, including T790M mutant and erlotinib-resistant H1975 cells. Ibrutinib(More)
BACKGROUND We recently showed that IGFBP2 is overexpressed in primary lung cancer tissues. This study aims to determine whether IGFBP2 is elevated in blood samples of lung cancer patients and whether its level is associated with clinical outcomes. METHODOLOGY/PRINCIPAL FINDINGS Plasma IGFBP2 levels were determined blindly by enzyme-linked immunosorbent(More)
In this paper, the existence of step-like contrast structure for a class of singularly perturbed optimal control problem is shown by the contrast structure theory. By means of direct scheme of boundary function method, we construct the uniformly valid asymptotic solution for the singularly perturbed optimal control problem. Finally , an example is presented(More)
Finite element method and analytic method are used to safety evaluation of a penstock laid on downstream surface of dam and its expansion pipe on the following issues: (i) Concrete cracking zone, maximum crack width and stress in liner and bars are calculated and analyzed with allowable value; (ii) Relative displacement at both sides of the joint between(More)
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