Hai-wen Zhou

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Oral leukoplakia (OL) is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk is unknown. The objective of this study is to estimate the rate of malignant transformation in a long-term follow-up cohort, explore the usefulness of(More)
OBJECTIVES The objectives of this study were to investigate the incidence of oral squamous cell carcinoma (OSCC) developing in lesions that were previously diagnosed as oral lichen planus (OLP), and to evaluate potential contributing factors that might be associated with an increased risk for the development of OSCC in these patients. STUDY DESIGN We(More)
Eotetranychus kankitus Ehara (Acari: Tetranychidae) is an important pest in Chinese citrus orchards. In the present study, we aimed to evaluate the potential of Neoseiulus barkeri (Hughes) (Acari: Phytoseiidae) for the biological control of E. kankitus. A two-sex life table of E. kankitus and N. barkeri was constructed to estimate development and fecundity.(More)
PURPOSE To explore the relationship of serum concentrations of osteopontin(OPN), TNF-α and TGF-β1 in Sjoigren's syndrome patients. METHODS Forty Sjoigren's syndrome (SS) patients were determined by pathological examination, which included 15 primary SS and 25 secondary SS. Serum level of OPN, TNF-alpha and TGF-beta 1 were examined by enzyme linked(More)
PURPOSE To introduce human telomerase reverse transcriptase (hTRT) into normal human oral keratinocytes(OKC) to expand their life-span. METHODS The pEGFP-hTRT was transferred into OKCs by lipofecAMINE2000 and transferring(TF). Expression of hTERT in transfectants was examined by fluorescence microscopy, laser confocal microscopy. Transfection efficiency(More)
PURPOSE Human telomerase reverse transcriptase (hTRT) was transfected into cultured oral keratinocytes (OKC) mediated by pBABE-tert recombined retrovirus to investigate the effect on OKC lifespan. METHODS pBABE-tert recombined retrovirus loaded with hTRT gene was amplified by transfected PT67 cells, and then transfected into cultured OKC in vitro. The(More)
PURPOSE To study oral precancerous lesion and oral cancer by using micro PET/CT. METHODS Thirty-nine SD rats were divided into experimental group and control group. 33 of them were raised with a 4-nitroquinoline-1-oxide (4NQO) solution with the concentration of 0.002% during the first 13 weeks, and then changed to normal water. The other 6 rats drank(More)
OBJECTIVE To construct a plasmid which has a reporter gene for exploring the role of human telomerase reverse transcriptase(hTRT) in in-vitro cell cultivation. METHODS hTRT was cut by restricted enzyme from plasmid pGRN145 and inserted to plasmid pEGFP-C1 (enhanced green fluorescent protein). RESULTS Restricted enzyme analysis and DNA sequencing showed(More)