Hai Yan

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An integrated genomic analysis of human glioblastoma multiforme.

Donald Williams Parsons, Siân Jones, +30 authors Kenneth W. Kinzler
Science
2008

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of… (More)

High frequency of mutations of the PIK3CA gene in human cancers.

Yardena Samuels, Zhenghe Wang, +12 authors Victor E. Velculescu
Science
2004

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility (1–3). To determine… (More)

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

Patrick J. Killela, Zachary J. Reitman, +34 authors Hai Yan
Proceedings of the National Academy of Sciences…
2013

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In… (More)

Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation

Peppi Koivunen, Sungwoo Lee, +14 authors William G Kaelin
Nature
2012

The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can… (More)

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

Patrick J. Killela, Christopher J. Pirozzi, +19 authors Darell D Bigner
Oncotarget
2014

Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics.… (More)

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

David A. Solomon, J Kim, +9 authors Todd Waldman
Cancer research
2008

An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy… (More)

Removal of cyanobacterial blooms in Taihu Lake using local soils. I. Equilibrium and kinetic screening on the flocculation of Microcystis aeruginosa using commercially available clays and minerals.

Gang Pan, Ming-Ming Zhang, Hao Chen, Hua Zou, Hai Yan
Environmental pollution
2006

Algal removal abilities of 26 clays/minerals were classified into three categories according to the 8-h equilibrium removal efficiency (Q8h) and removal rate at a clay loading of 0.7 g/L. Type I… (More)

Isocitrate dehydrogenase mutations in gliomas.

Matthew S Waitkus, Bill H Diplas, Hai Yan
Neuro-oncology
2016

Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our understanding of glioma genetics was revolutionized when mutations in… (More)

Somatic Mutations in the Chromatin Remodeling Gene ARID1A Occur in Several Tumor Types

Siân Jones, Meng Li, +18 authors Nickolas Papadopoulos
Human mutation
2012

Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutations in other tumor… (More)

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

Christopher G Duncan, Benjamin G Barwick, +7 authors Hai Yan
Genome research
2012

Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with… (More)

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