• Publications
  • Influence
Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation
TLDR
Comparisons of 12 combinations of eight promoters and two terminators found that the efficiency of the egg cell-specific promoter-controlled CRISPR/Cas9 system depended on the presence of a suitable terminator, and the composite promoter generated by fusing two eggcell-specific promoters resulted in much higher efficiency of mutation in the T1 generation compared with the single promoters. Expand
A CRISPR/Cas9 toolkit for multiplex genome editing in plants
TLDR
A toolkit that facilitates transient or stable expression of the CRISPR/Cas9 system in a variety of plant species, which will facilitate plant research, as it enables high efficiency generation of mutants bearing multiple gene mutations. Expand
Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer.
TLDR
Up-regulation of Foxp3 could be a novel approach for inhibiting ovarian cancer progression by inhibiting cell proliferation, decreased cell migration, and reduced cell invasion in epithelial ovarian cancer cell lines. Expand
Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention
TLDR
The results suggest that in plants, continuous attention should be paid to off-target effects induced by CRISPR/Cas9 in current and subsequent generations, and that the tools optimized in this report will be useful in improving genome editing efficiency and specificity in plants and other organisms. Expand
Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice
TLDR
The data indicate that the effects of normal aging in C57B6xSJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Abeta load only affects discrimination reversal learning in this study. Expand
MiR‐139 Inhibits Mcl‐1 Expression and Potentiates TMZ‐Induced Apoptosis in Glioma
TLDR
This study explored the involvement of micro‐RNAs that acted as endogenous sequence‐specific suppressors of gene expression in human glioblastoma and found that Bcl‐1 is overexpressed in humans, conferring a survival advantage to tumor cells. Expand
Wharton’s jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction
TLDR
WJ-MSCs transplanted by a direct injection into the infarcted area could survive and differentiate into cardiomyocytes and endothelial cells and promoted recruitment and differentiation of cardiac stem cells in a porcine model with AMI. Expand
Huperzine A exhibits anti‐inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia
TLDR
It is demonstrated that huperzine A exhibits neuroprotective effects against transient focal cerebral ischemia‐induced brain injury and suggested that the protection mechanism may involve a cholinergic anti‐inflammatory pathway, in which nAChR plays an essential role. Expand
A multicenter randomized open-label study of rituximab plus rhTPO vs rituximab in corticosteroid-resistant or relapsed ITP.
TLDR
It is demonstrated that the combination of RTX and rhTPO significantly increased the CR rate and shortened TTR compared with RTX monotherapy in the treatment of corticosteroid-resistant or relapsed ITP but failed to show a beneficial effect on the long-lasting response. Expand
Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development
TLDR
Questions about its genetoxicity and hepatotoxicity were discussed during its safety study to make the foundation for long-term medication and clinical research in the near future. Expand
...
1
2
3
4
5
...