Hai-Yan Yang

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BACKGROUND The most common mechanisms of multidrug resistance (MDR) in cancer cells is the expression of an energy-dependent exfflux pump. P-glycoprotein (P-gp) encoded by MDR1 gene and multidrug associated protein (MRP) are well known proteins associated with MDR. In human cancers, the MDR1 gene expression is common in patients with intrinsic and acquired(More)
BACKGROUND Id (inhibitor of differentiation/DNA binding)-1 and -3 are involved in neoangiogenesis; they antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. The aim of this study was to investigate Id-1 and -3 expression in gastric tumors and their clinical relevance in gastric cancer. MATERIALS AND METHODS(More)
Inhibitors of DNA binding/inhibitors of differentiation (Id) protein family (Id-1, -2, -3 and -4) of helix-loop-helix proteins have been shown to be involved in carcinogenesis and are regarded as prognostic markers in several types of human cancers. However, the roles of Id proteins during breast carcinoma progression remain unclear. The objective was to(More)
In this paper, we present a new sketch-based system - KnitSketch, to improve the efficiency of process planning for knitting garments at an early design stage. The KnitSketch system utilizes sketching interface with the pen-paper metaphor and users only need to draw outlines of different parts of the garment. Based on sketching understanding, the system(More)
The tumor-suppressor ING3 has been shown to be involved in tumor transcriptional regulation, apoptosis and the cell cycle. Some studies have demonstrated that ING3 is dysregulated in several types of cancers. However, the expression and function of ING3 in human hepatocellular carcinoma (HCC) remains unclear. The aim of this study is to investigate ING3(More)
OBJECTIVE To establish a two-dimensional polyacrylamide gel electrophoresis (2-DE) map of human low differentiation nasopharyngeal carcinoma (NPC) cell line CNE-2 proteome. METHODS Immobilized pH gradient 2-DE was applied to separate the total proteins of CNE-2 cells, matrix-assisted laser desorption/ionization-time of flight mass spectrometry(More)
OBJECTIVE To investigate the clinicopathological features of primary gastrointestinal non-Hodgkin's lymphomas (PGI-NHL) and their prognostic values. METHODS The clinical and pathological data of 216 patients diagnosed as PGI-NHL from Zhejiang Cancer Hospital were analyzed retrospectively. χ² test, log-liner model analysis, COX proportional hazard(More)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with few therapeutic options. Recently, insight into cancer biology suggested abnormal lipid metabolism to be a risk factor for human malignancies. As a key enzyme implicated in lipid metabolism, PLD1 was elevated in various human cancer associating with malignant phenotypes. However, little was(More)
The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publica tion Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.
Euonymus alatus (E. alatus) has been used as a folk medicine for diabetes in China for more than one thousand years. In order to identify major active components, effects of different fractions of E. alatus on the plasma glucose levels were investigated in normal mice and alloxan-induced diabetic mice. Our results show that ethyl acetate fraction (EtOAc(More)