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Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro
Abstract 1. The aim of this study was to identify the hepatic metabolic enzymes, which involved in the biotransformation of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleosideExpand
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Interaction between 3,4‐dichlorophenyl‐propenoyl‐sec.‐butylamine (3,4‐DCPB), an antiepileptic drug, and cytochrome P450 in rat liver microsomes and recombinant human enzymes in vitro
ABSTRACT The compound 3,4‐dichlorophenyl‐propenoyl‐sec.‐butylamine (3,4‐DCPB) is an antiepileptic drug. The purpose of the present research was to identify cytochrome P450 (CYP450) responsible forExpand