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The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and other vertebrates. Copy number variations (CNVs) are a form of genomic structural variation widely distributed in the genome. CNV analysis has recently gained greater attention and momentum, as the identification of CNVs can contribute to a(More)
BACKGROUND The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METHODS Institutional(More)
Emergence of resistance to imatinib mesylate complicates the treatment of chronic myeloid leukemia (CML). Second-generation tyrosine kinase inhibitors are capable to overcome resistance mediated by most mutations except T315I. As this mutation is causative for 20% of clinically observed resistances, the need for novel treatment strategies becomes obvious(More)
PURPOSE To investigate whether celastrol could show synergism combined with lapatinib in HepG2 human hepatocellular carcinoma (HCC) cell line in vitro. METHODS The effects of treatment with lapatinib and/or celastrol on cell growth were determined using MTT assay. Drug synergy was determined using combination index (CI) methods derived from Chou-Talalay(More)
Hepatitis B virus X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). Emerging evidence has shown the association between aberrantly expressed miR-221 and cancer development; however, little is known concerning its potential role in hepatitis B virus (HBV)-related HCC. In the present study, functional studies(More)
BACKGROUND & OBJECTIVE Nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the incidence of gastrointestinal neoplasms with inhibition of cyclooxygenase-2 (COX-2). This study was designed to investigate the expression and significance of COX-2 and the relationship between COX-2 and bcl-2 in human pancreatic carcinoma. METHODS COX-2 and bcl-2 expression(More)
bcr/abl fusion gene is thought to be a promising target for chronic myelogenous leukemia (CML) patients to enhance immune response after attaining complete remission. In this study, we sought to enhance cellular immunity by co-expression of BCR/ABL and murine IL-12 gene on the tumor cell surface as a glycosyl-phosphatidylinositol (GPI)-form. The(More)
A field experiment was conducted to study the effects of full period and growth period straw mulching with an amount of 3000, 6000, and 9000 kg x hm(-2) on the soil aggregates in a no-tillage dryland wheat field in Weibei Loess Pleateau of Shaanxi Province, taking no full period straw mulching as the control. In the 0-40 cm soil layer, the content of > 5 mm(More)