We present supervised machine-learning approaches to automatically classify medical questions based on a hierarchical evidence taxonomy created by physicians. We show that SVMs is the best classifier for this task and that a ladder approach, which incorporates the knowledge representation of the hierarchical evidence taxonomy, leads to the highest… (More)
Physicians have many questions when caring for patients, and frequently need to seek answers for their questions. Information retrieval systems (e.g., PubMed) typically return a list of documents in response to a user's query. Frequently the number of returned documents is large and makes physicians' information seeking "practical only 'after hours' and not… (More)
The interaction of a pair of weakly coupled biological bursters is examined.Bursting refers to oscillations in which an observable slowly alternates between phases of relative quiescence and rapid oscillatory behavior. The motivation for this work is to understand the role of electrical coupling in promoting the synchronization of bursting electrical… (More)
Tumor-initiating cell (TIC) is a subpopulation of cells in tumors that are responsible for tumor initiation and progression. Recent studies indicate that hepatocellular carcinoma-initiating cells (HCICs) confer the high malignancy, recurrence and multi-drug resistance in hepatocellular carcinoma (HCC). In this study, we found that Icaritin, a… (More)
We are developing a biomedical question answering system. This paper describes our system's architecture and our question analysis component. Specifically, we have explored the use of various supervised machine learning approaches to filter out unanswerable questions based on physicians' annotations.
Lung cancer is the leading cause of cancer-related death in both men and women. Lung cancer contains a small population of cancer cells with stem-like features known as cancer stem cells (CSCs). CSCs are often more resistant to current therapeutic treatments. Thus, it is urgent to develop a novel agent that is able to inhibit CSCs growth. In this study, we… (More)