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MOTIVATION Pathway modeling requires the integration of multiple data including prior knowledge. In this study, we quantitatively assess the application of Gene Ontology (GO)-derived similarity measures for the characterization of direct and indirect interactions within human regulatory pathways. The characterization would help the integration of prior(More)
During wound healing, stem cells provide functional mature cells to meet acute demands for tissue regeneration. Simultaneously, the tissue must maintain a pool of stem cells to sustain its future regeneration capability. However, how these requirements are balanced in response to injury is unknown. Here we demonstrate that after wounding or ultraviolet type(More)
1. Voltage-dependent properties of isolated guinea pig outer hair cells (OHCs) were investigated using whole-cell recording. An inward current was detected in approximately 10% of the cells. This inward current was identified as belonging to the voltage-activated sodium current family on the basis of its high sensitivity to tetrodotoxin and the effect of(More)
Terrain is an ordered surface where locations relate to each other through their elevations. Preservation of this topo-graphic orderliness by an interpolation method so that " if point A is higher than point B in the terrain, the interpolated elevation of A remains higher " is important to assure the practical value of the resultant DEM. Based on the(More)
Dynamic Random Testing (DRT) is a testing strategy to improve traditional random testing and random-partition testing strategies. The essential idea of DRT is that the testing profile, based on which test classes are chosen to select next test case, should be dynamically adjusted according to the testing history. DRT can have various forms depending on(More)
The Active Straight Leg Raise (ASLR) is an important test in diagnosing pelvic girdle pain (PGP). It is difficult to understand what happens normally during the ASLR, let alone why it would be impaired in PGP. In the present study, healthy subjects performed the ASLR under normal conditions, with weight added above the ankle, and while wearing a pelvic(More)
In speeding-up normal walking, relative phase between horizontal thorax and pelvis rotations changes from more in-phase (synchronous) to more out-of-phase. In pathology (stroke, Parkinson's disease, low-back pain, pregnancy-related pelvic girdle pain), this often fails to happen. Even in healthy gait, however, these phenomena remain poorly understood.(More)
Cholesterol supersaturation of bile is one prerequisite for gallstone formation. In the present study of Chinese patients with gallstones, we investigated whether this phenomenon was correlated with the hepatic expression of genes participating in the metabolism of cholesterol and bile acids. Twenty-two nonobese, normolipidemic patients (female-male, 11:11)(More)