Hai H. Nguyen

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Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4-deficient mice develop fatal, early onset lymphoproliferative disease. However, chimeric mice containing both CTLA-4-deficient and -sufficient(More)
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory receptor on T cells essential for maintaining T cell homeostasis and tolerance to self. Mice lacking CTLA-4 develop an early onset, fatal breakdown in T cell tolerance. Whether this autoimmune disease occurs because of the loss of CTLA-4 function in regulatory T cells, conventional T cells, or both(More)
The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexity has been widely disseminated. Here we(More)
The Semantic Web represents an evolution of the World Wide Web towards one of entities and their relationships , rather than pages and links. Such a progression makes it possible to represent, integrate, query and reason about structured online data. Recent years have witnessed tremendous growth of mobile computing, represented by the widespread adoption of(More)
FOXP3-expressing regulatory T (Treg) cells are vital for maintaining peripheral T cell tolerance and homeostasis. The mechanisms by which FOXP3 target genes orchestrate context-dependent Treg cell function are largely unknown. In this study we show that in mouse peripheral lymphocytes the Drosophila Disabled-2 (Dab2) homolog, a gene that is involved in(More)
In many logic-based BDI agent programming languages, plan selection involves inferencing over some underlying knowledge representation. While context-sensitive plan selection facilitates the development of flexible, declarative programs, the overhead of evaluating repeated queries to the agent's beliefs and goals can result in poor run time performance. In(More)
The CURIOS project explores how digital archives for rural community heritage groups can be made more sustainable so that volunteer members can maintain a lasting digital presence. It is developing software tools to help remote rural communities to collaboratively maintain and present information about their cultural heritage. The objective is to(More)
We describe a tool, MatchMaps, that generates sameAs and partOf matches between spatial objects (such as shops, shopping centres, etc.) in crowd-sourced and authoritative geospatial datasets. MatchMaps uses reasoning in qualitative spatial logic, description logic and truth maintenance techniques, to produce a consistent set of matches. We report the(More)