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Bioactive triterpene glycosides from the sea cucumber Holothuria fuscocinerea.
Three new triterpene glycosides are isolated as active compounds causing morphological abnormality of Pyricularia oryzae mycelia and showed in vitro cytotoxicity against two human tumor cell lines. Expand
A New Cytotoxic Lanostane‐Type Triterpene Glycoside from the Sea Cucumber Holothuria impatiens
The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide against seven different human tumor cells, with IC50 values of 0.37–2.75 μg/ml. Expand
Antifungal triterpene glycosides from the sea cucumber Bohadschia marmorata.
Four new holostan-type triterpene glycosides were isolated from the sea cucumber Bohadschia Marmorata Jaeger and exhibited significant antifungal activity against six strains. Expand
Isolation and structure of the cytotoxic cycloheptapeptide phakellistatin 13.
The structure was elucidated as cyclo-(Pro1-Trp-Leu-Thr-Pro2-Gly-Phe) on the basis of MS, UV, IR, and high-field NMR analysis, and the compound was significantly cytotoxic against the human hepatoma BEL-7404 cell line with an ED(50) < 10(-2) microg/mL. Expand
Saponin 1 Induces Apoptosis and Suppresses NF-κB-Mediated Survival Signaling in Glioblastoma Multiforme (GBM)
The results suggest that saponin 1 exhibits significant in vitro and in vivo anti-tumor efficacy and merits further investigation as a potential therapeutic agent for GBM. Expand
Saponin B, a novel cytostatic compound purified from Anemone taipaiensis, induces apoptosis in a human glioblastoma cell line.
- Y. Wang, Hai-Feng Tang, +6 authors Z. Fei
- Biology, Medicine
- International journal of molecular medicine
- 1 November 2013
The novel compound, saponin B, effectively induces the apoptosis of GBM cells and inhibits glioma cell growth and survival and may be a potential candidate for the development of novel cancer therapeutics with antitumor activity against gliomas. Expand
Bioactive asterosaponins from the starfish Culcita novaeguineae.
- Hai-Feng Tang, Y. Yi, L. Li, P. Sun, San-qi Zhang, Yue-ping Zhao
- Chemistry, Medicine
- Journal of natural products
- 19 February 2005
Two new sulfated steroidal pentaglycosides (asterosaponins) were isolated from the starfish Culcita novaeguineae and showed marginal in vitro cytotoxicity against two human tumor cell lines. Expand
New Cytotoxic Oxygenated Sterols from the Marine Bryozoan Cryptosula pallasiana
- Xiang-rong Tian, Hai-Feng Tang, +5 authors Ping-Hu Zhang
- Biology, Medicine
- Marine drugs
- 28 January 2011
Six new sterols were isolated from the CCl4 extract of the marine bryozoan Cryptosula pallasiana, and this is the first time that these compounds (3-6) are reported as natural sterols. Expand
Asterosaponin 1, a cytostatic compound from the starfish Culcita novaeguineae, functions by inducing apoptosis in human glioblastoma U87MG cells
The data demonstrate that asterosaponin 1 is fully equipped for an efficient apoptotic killing of glioblastoma cells and suggest that this mechanism may play a critical role in anti-tumor chemotherapy. Expand
Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus.
A new triterpene glycoside along with the known intercedenside B was isolated from the sea cucumber Pseudocolochirus violaceus and exhibited significant cytotoxicity against cancer cell lines MKN-45 and HCT-116. Expand