Hafeez Ur Rehman

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Boolean Networks are emerging as a simple yet powerful formalism to model and study Gene Regulatory Networks. Nevertheless, the most widely used Boolean Network-based models do not include any post-transcriptional regulation mechanism. In this paper we discuss how the post-transcriptional regulation mechanism mediated by miRNAs can be included in a Boolean(More)
A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for(More)
Keywords: MiRNA Gene regulatory networks Post-transcriptional regulation Boolean networks Complex systems Network analysis a b s t r a c t Gene regulatory networks (GRNs) model some of the mechanisms that regulate gene expression. Among the computational approaches available to model and study GNRs, Boolean network (BN) emerged as very successful to better(More)
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