Haeng-Boo Kim

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BACKGROUND Gel-type autologous chondrocyte (Chondron) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron at many clinical centers at various time points during the postoperative patient follow-up. METHODS Data from 98 patients with articular cartilage(More)
We developed a fabrication method and a liquid filling method for a nano chemical reactor that used Y-shaped nanochannels specially designed for mixing and reacting. In order to reduce the pressure loss and to utilize the characteristics of the nanochannel, inlet microchannels were fabricated just beside the nanochannels. We investigated an initial liquid(More)
Protein refolding using a simple dilution method in a microchannel often led to the formation of protein aggregates, which bound to the microchannel wall, resulting in low refolding yields. To inhibit aggregation and improve refolding yields, an artificial chaperone-assisted (ACA) refolding, which employed detergents and beta-cyclodextrin was used. Model(More)
We have fabricated nanometer-sized channels, demonstrated a technique for the introduction of liquid into the channels, and carried out time-resolved fluorescence measurements of aqueous solutions. In this study, 330-nm- and 850-nm-sized channels were fabricated on fused-silica substrates by fast atom beam etching and hydrofluoric acid bonding methods. A(More)
A rapid micromixer of fluids in a microchannel is presented. The mixer uses AC electroosmotic flow, which is induced by applying an AC voltage to a pair of coplanar meandering electrodes configured in parallel to the channel. To demonstrate performance of the mixer, dilution experiments were conducted using a dye solution in a channel of 120 microm width.(More)
The mixing of fluids using AC electrothermal flow (AC-ETF) is presented. A pair of coplanar electrodes with a sinusoidal interelectrode gap was used to enhance the mixing in a microchannel. To demonstrate the performance of the mixer, conventional dilution experiments were conducted using Texas Red-labeled dextran. The dependence of mixing on the salt(More)
We have reported on a novel microfluidic mixer based on AC electroosmosis. To elucidate the mixer characteristics, we performed detailed measurements of mixing under various experimental conditions including applied voltage, frequency and solution viscosity. The results are discussed through comparison with results obtained from a theoretical model of AC(More)
By using characteristics of titania nanoparticles, a patterning and tuning method of microchannel surface wettability was developed for microfluid control. Titania modification of a microchannel provided a nanometer-sized surface roughness and the subsequent hydrophobic treatment made the surface superhydrophobic. Photocatalytic decomposition of the coated(More)
Polymer microchannel chips (dimension of the channel, 20 microm (depth) x 100 microm (width)) integrated with dual microband electrodes were fabricated by an imprinting method, and their characteristic electrochemical responses were elucidated in detail. A silicon micromachined template fabricated by photolithography and dry etching techniques was used for(More)
A microspectroscopy system combined with a fluid manifold was developed to manipulate and analyze "single" living cells. A sample buffer solution containing living cells was introduced into a flow cell set on a thermostated microscope stage and a few cells were allowed to attach to the bottom wall of the flow cell. With these living cells being attached to(More)