Hae-Eul Lee

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S100A8 and S100A9 are members of the S100A8 protein family that exist as homodimers and heterodimers in neutrophils, monocytes, and macrophages. Recent studies have shown the pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis. We found significant up-regulation of S100A8 and S100A9 secretion(More)
Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect of Nrf2 on melanogenesis in normal human melanocytes (NHMCs). When NHMCs were transduced with a recombinant adenovirus expressing Nrf2, melanin synthesis was significantly decreased. Consistent(More)
BACKGROUND Adenosine is a nucleoside, in which an adenine molecule is attached to a ribofuranose sugar moiety. It can be released into the microenvironment by metabolically active cells, and then fulfills a multitude of functions in regulation of cell proliferation, by activating four subtypes of G protein-coupled adenosine receptors. OBJECTIVE In this(More)
Vol. 29, No. 2, 2017 241 Received October 27, 2015, Revised March 17, 2016, Accepted for publication April 8, 2016 Corresponding author: Jeung-Hoon Lee, Department of Dermatology, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. Tel: 82-42-280-7707, Fax: 82-42-280-8459, E-mail: Jhoon@cnu.ac.kr This is an Open Access(More)
BACKGROUND Alopecia areata (AA), a chronic, relapsing hair-loss disorder, is considered to be a T-cell-mediated autoimmune disease. High-mobility group box 1 (HMGB1), released by necrotic cells and in response to various inflammatory stimuli, is currently considered to be a significant target antigen in diverse autoimmune diseases. OBJECTIVE We sought to(More)
Lipedematous alopecia is a rare condition of unknown etiology characterized by a thick boggy scalp with varying degrees of hair loss. It is usually seen in adult African-American females, and a case in a 9-year-old was the youngest patient reported thus far. We report on the appearance of this condition in two children, a 6-year-old child and a 10-year-old(More)
260 Ann Dermatol Received December 2, 2014, Revised April 7, 2015, Accepted for publication May 6, 2015 Corresponding author: Young-Joon Seo, Department of Dermatology, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. Tel: 82-42-280-7700, Fax: 82-42-280-8459, E-mail: joon@cnu.ac.kr This is an Open Access article(More)
Vol. 29, No. 5, 2017 655 Received January 5, 2016, Revised August 21, 2016, Accepted for publication October 4, 2016 Corresponding author: Jeung-Hoon Lee, Department of Dermatology, Chungnam National University School of Medicine, 266 Munhwa-ro, Jung-gu, Daejeon 35015, Korea. Tel: 82-42-280-7707, Fax: 82-42-2808459, E-mail: Jhoon@cnu.ac.kr This is an Open(More)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fig. 1. (A) At the time of the first visit, the(More)