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  • Francisco M. de la Vega, Hadar I. Isaac, Charles R. Scafe
  • Medicine, Computer Science, Biology
  • Pacific Symposium on Biocomputing
  • 2006 (First Publication: 1 December 2005)
  • The design of genetic association studies using single-nucleotide polymorphisms (SNPs) requires the selection of subsets of the variants providing high statistical power at a reasonable cost. SNPsContinue Reading
  • Francisco M. De La Vega, Hadar I. Isaac, +26 authors D. A. Gilbert
  • Medicine, Biology
  • Genome research
  • 2005 (First Publication: 21 March 2005)
  • The extent and patterns of linkage disequilibrium (LD) determine the feasibility of association studies to map genes that underlie complex traits. Here we present a comparison of the patterns of LDContinue Reading
  • Francisco M. De La Vega, Derek Gordon, +4 authors Eugene G. Spier
  • Medicine, Biology
  • Human Heredity
  • 2005
  • Power and sample size calculations are critical parts of any research design for genetic association. We present a method that utilizes haplotype frequency information and average marker-markerContinue Reading