Hadar I. Isaac
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The design of genetic association studies using single-nucleotide polymorphisms (SNPs) requires the selection of subsets of the variants providing high statistical power at a reasonable cost. SNPs… Continue Reading
The extent and patterns of linkage disequilibrium (LD) determine the feasibility of association studies to map genes that underlie complex traits. Here we present a comparison of the patterns of LD… Continue Reading
Power and sample size calculations are critical parts of any research design for genetic association. We present a method that utilizes haplotype frequency information and average marker-marker… Continue Reading
Open Access Open Access option. Genome Research Freely available online through the License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at as a Creative Commons… Continue Reading
Applied Biosystems developed a first generation whole-genome, gene-centric reference SNP map for use in candidate-gene, candidate-region, and eventually whole-genome disease association studies. The… Continue Reading