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Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the
TLDR
Zerumbone is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies, and alpha-humulene, a structural analog lacking only the carbonyl group in ZER, was virtually inactive in all experiments conducted, indicating that the alpha,beta-unsaturated carbony l group may play some pivotal roles in interactions with unidentified target molecule(s).
Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell–Cell Adhesions in Endothelial Cells
TLDR
Induction of PTP1B by hindlimb ischemia may represent an important counterregulatory mechanism that blunts overactivation of VEGFR2 during angiogenesis in vivo and stabilizes cell–cell adhesions through reducing tyrosine phosphorylation of VE-cadherin.
Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia
TLDR
Hindlimb ischemia of mice significantly increases Nox2 expression and ROS production in BM-mononuclear cells (BMCs), which is associated with an increase in circulating EPC-like cells, which plays a critical role in mobilization, homing, and angiogenic capacity of EPCs and BM stem/progenitor cells, thereby promoting revascularization of ischemic tissue.
Effects and Mechanisms of Taurine as a Therapeutic Agent
TLDR
Taurine is extremely effective in the treatment of the mitochondrial disease, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes, and offers a new approach for the Treatment of metabolic diseases, such as diabetes, and inflammatory diseases,such as arthritis.
Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
TLDR
The elucidation of β-glucan and its signaling pathway will undoubtedly open a new research area on its potential therapeutic applications, including as immunostimulants for antifungal and anti-cancer regimens.
Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction
TLDR
A novel role of exosomes derived from MSCCR4 is revealed and a new mechanism of intercellular mediation of stem cells for MI treatment is highlighted, highlighting a new way of inter cellular mediation for recovery of cardiac functions after myocardial infarction.
Extracellular SOD-Derived H2O2 Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice
TLDR
It is suggested that ecSOD binding to ECs via HBD is required for localized generation of extracellular H2O2 to regulate VEGFR2-pY, which is a potential therapeutic target for angiogenesis-dependent cardiovascular diseases.
IQGAP1 Mediates VE-Cadherin–Based Cell–Cell Contacts and VEGF Signaling at Adherence Junctions Linked to Angiogenesis
TLDR
IQGAP1 is required for establishment of cell–cell contacts in quiescent ECs to induce angiogenesis and may function to link VEGFR2 to the VE-cadherin containing adherens junctions, thereby promoting VEGF-stimulated, ROS-dependent tyrosine phosphorylation of VE–cells contacts and loss of cell-cell contacts.
Evaluation on Natural Background of the Soil Heavy Metals in Korea
This study was conducted in order to get the scientific background for soil pollution criteria. The 92 soil samples derived from various geological units were taken and analyzed to survey natural
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