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OBJECTIVE To compare the cost effectiveness of two possible modifications to the current UK screening programme: shortening the screening interval from three to two years and extending the age of invitation to a final screen from 64 to 69. DESIGN Computer simulation model which first simulates life histories for women in the absence of a screening(More)
The application of agarose in hemoperfusion is hampered by the lack of a suitable sterilization method. A technique has been developed for the crosslinking of agarose encapsulated sorbents by the reaction with 1,3-dichloro-2-propanol (DCP) under strong alkaline conditions. A twofold molar excess of DCP with respect to agarose and an equimolar amount of(More)
Aim To determine the agreement of manual and semi-automatic (SA) diameter and volume measurements of nodules found in low-dose computed tomography lung cancer screening. Methods Baseline data of 2,240 solid intermediate-sized nodules (volume 50-500mm 3) in 1,498 Dutch-Belgian NELSON trial participants were used. Extrapolated volume based on semi-automatic(More)
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