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This work confirms the previous observation that a single application of N-hydroxy-2-fluorenylacetamide or N-hydroxy-3-fluorenylacetamide to the mammary gland of the rat induced a high incidence of tumors, whereas the corresponding arylamides, N-2-fluorenylacetamide (2-FAA) and N-3-fluorenylacetamide, were only weakly active. The results suggested(More)
The effect of chronic ethanol consumption by rats on hepatic microsomal activation of the hepatocarcinogens dimethylnitrosamine (DMN) and 2-acetylaminofluorene (2-AAF) was investigated. There was a marked increase in the rate of the oxidative demethylation of DMN and its activation to a mutagen by microsomes following ethanol intake. N- and C-hydroxylation(More)
The mechanism by which a chemical agent binds to proteins is of considerable interest, particularly since a large number of compounds with carcinogenic activity have been found to bind firmly to cellular proteins at the site of tumor formation. Included in this category are the polycyclic aromatic hydrocarbons (l), the aminoazo dyes (2),(More)