HARALD E. REFSUM

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A total of 149 patients in 7 centers in Denmark, Norway and Sweden entered a 6-week double-blind trial intended to assess the antidepressant effect and safety of citalopram vs placebo in depressed elderly patients (65 years of age or older) who might also suffer from somatic disorders and/or senile dementia. Results of ratings on the Hamilton Rating Scale(More)
Pulmonary function and pulmonary gas exchange at rest, and during and after a standard exercise load of 500 kpm in 1 min on bicycle ergometer were studied in 34 women with severe, uncomplicated obesity, aged 37.8 (20-59) years, before and 1 year after gastric banding, resulting in a weight loss from 113.2 (84-156) to 81.7 (60-110) kg. Following the weight(More)
Serum and urine osmolality and creatinine were measured in fifty-eight well-trained men, aged 21-57 years, in connection with three 70 km cross-country ski races taking place under essentially the same external circumstances, leading to slight dehydration. Although the race urine flow was low, 0.51 (0.05-1.10) ml/min, the urine osmolality and the urine to(More)
To test the applicability of indirect estimation of daily energy expenditure from average daily heart rate (HR) and individual O2-intake/heart rate (VO2/HR) regression lines in subjects with metabolic disorders, VO2/HR regression lines were determined on 2 consecutive days in 17 subjects (five healthy, five with obesity, five with untreated thyrotoxicosis,(More)
Thirty seven workers employed for at least three years in oil impregnation of cables during 1963-83 were followed up in 1990 to study the development of pulmonary fibrosis and consequences for lung function. They had been exposed to concentrations of mineral oil vapours of 50-100 mg/m3, and concentrations of oil mist of 0.5-1.5 mg/m3. All 29 living persons(More)
Serum and urine electrolytes, creatinine, and urea were determined in 21 well-trained men, aged 21-56 years, in connection with a 70-km cross-country ski race, lasting 4.39-6.52 h, leading to slight dehydration. Although the race urine flow was low, averaging 0.41 (0.1-0.9) ml/min, the average urine concentrations of urea, Na, Ca, Mg, Cl and P were markedly(More)
Erythrocyte 2,3-DPG, PO2 50%, whole blood hemoglobin and available O2, and fixed acid Bohr effect were studied during the first 10 days after birth in rapidly growing suckling rabbits. The post-natal fall in hemoglobin concentration was accompanied by a marked rise in erythrocyte 2,3-DPG and a gradual increase in PO2 50%. The rise in PO2 50% was sufficient(More)
The erythropoietic activity and erythrocyte 2,3-diphosphoglycerate (2,3-DPG) were studied during and after the nadir of the post-natal anaemia in normal, rapidly growing rabbits, from the 12th to the 35th day after birth. Whole blood haemoglobin (Hb) decreased from 9.3 g dl-1 on the 12th to 4.9 g dl-1 on the 25th day, while erythropoiesis-stimulating(More)
Previous studies of the influence of physical exercise on erythrocyte 2,3-DPG have shown conflicting results, including that exercise induces increase, decrease or no changes in 2,3-DPG. Assuming that the interplay between the factors governing 2,3-DPG metabolism may change considerably during the early phase of recovery after exercise, the level of(More)