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How best to analyse statistically experimental results that are set out as a 2 x 2 table of frequencies has been debated by statisticians for more than 50 years. The main issue is what framework of statistical inference should be adopted. The design of most biomedical experiments that result in 2 x 2 tables of independent observations is compatible with the(More)
The first step in making inferences under the frequentist system of statistical logic is to propose a null hypothesis. An experiment is then performed, or a set of observations made. The resulting data are subjected to statistical analysis to determine whether the null hypothesis should be rejected or not. If it is, then some alternative hypothesis must(More)