HA Ménard

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A Prostaglandin endoperoxide synthase isoenzyme was recently identified in several cell lines. Osteoblasts possess Prostaglandin endoperoxide synthase activity, but it is not known which isoenzymes are present in these cells. Our objective was to identify these isoenzymes in human osteoblasts. Resting cells in culture did not produce measurable amounts of(More)
The recent discovery of cyclooxygenase-2 (COX-2), an isoenzyme associated mainly with inflammation created the need to reevaluate cyclooxygenase inhibitors with reliable screening methods. In the present study we standardized a technique to determine the IC50S of cyclooxygenase inhibitors on recombinant human COX-1 and COX-2 expressed in mammalian cells and(More)
Collagen arthritis is an experimental model for rheumatoid arthritis which is induced in susceptible DBA/1 mice after immunization with native type II collagen (CII). All immunized mice exhibit a humoral response to CII regardless of the occurrence of articular pathology. In order to further analyze the determinants recognized on the CII molecule, we have(More)
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