H. von der Hardt

Publications114
h-index28
Citations2,768
Highly Influential Citations76
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Commercial versus native surfactants. Surface activity, molecular components, and the effect of calcium.
Despite their broad clinical use, there is no standardized comparative study on the functional, biochemical, and morphologic differences of the various commercial surfactants in relation to native… Expand
  • 181
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Placebo‐controlled, double‐blind, randomized study of aerosolized tobramycin for early treatment of Pseudomonas aeruginosa colonization in cystic fibrosis
In chronic Pseudomonas aeruginosa pulmonary infection of patients with cystic fibrosis (CF), antibiotic therapy generally fails to eradicate the bacterial pathogen. The mucoid bacterial phenotype,… Expand
  • 187
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Genome fingerprinting of Pseudomonas aeruginosa indicates colonization of cystic fibrosis siblings with closely related strains.
The epidemiology of Pseudomonas aeruginosa infection at a cystic fibrosis (CF) center was monitored over a 3-year period. A total of 835 isolates from 72 unrelated patients and 22 siblings with CF… Expand
  • 218
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Conductive airway surfactant: surface-tension function, biochemical composition, and possible alveolar origin.
Alveolar surfactant is well known for its ability to reduce minimal surface tension at the alveolar air-liquid interface to values below 5 mN/m. In addition, it has been suggested that an analogous… Expand
  • 119
  • 5
DNA concentration and length in sputum of patients with cystic fibrosis during inhalation with recombinant human DNase.
BACKGROUND--The clinical benefit of the administration of aerosolised recombinant human DNase (rhDNase) on pulmonary function in patients with cystic fibrosis has already been demonstrated but the… Expand
  • 64
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Phosphatidylcholine molecular species in lung surfactant: composition in relation to respiratory rate and lung development.
Surfactant reduces surface tension at the air-liquid interface of lung alveoli. While dipalmitoylphosphatidylcholine (PC16:0/ 16:0) is its main component, proteins and other phospholipids contribute… Expand
  • 102
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Nosocomial acquisition of Pseudomonas aeruginosa by cystic fibrosis patients.
During a 4-year period, at least 12 of 40 patients with cystic fibrosis (CF) who were newly colonized with Pseudomonas aeruginosa had acquired it at CF recreation camps, clinics, or rehabilitation… Expand
  • 120
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Resting energy expenditure before and after treatment for Pseudomonas aeruginosa infection in patients with cystic fibrosis.
To investigate whether metabolic rates change after antipseudomonal treatment, resting energy expenditure (REE) was measured in 29 patients with cystic fibrosis (CF) aged 5-27 y before and after a… Expand
  • 44
  • 3
Energy Supplements Rich in Linoleic Acid Improve Body Weight and Essential Fatty Acid Status of Cystic Fibrosis Patients
Background Patients with cystic fibrosis who have steatorrhea frequently are underweight and have essential fatty acid (EFA) depletion, which is associated with a poor clinical course. It has been… Expand
  • 69
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Cost of care and clinical condition in paediatric cystic fibrosis patients.
BACKGROUND The clinical course of cystic fibrosis (CF) shows considerable variation resulting in differences in health care utilisation. We investigated important clinical parameters and their… Expand
  • 79
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