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Characterization of glutathione conjugates of the remoxipride hydroquinone metabolite NCQ-344 formed in vitro and detection following oxidation by human neutrophils.
- J. Erve, M. Svensson, H. von Euler-Chelpin, E. Klasson-Wehler
- Chemistry, Medicine
- Chemical research in toxicology
- 30 March 2004
It is demonstrated that NCQ-344 is capable of facile formation of a reactive para-quinone capable of reacting with GSH and may rationalize previous findings regarding the biological effects observed in vitro with these two remoxipride metabolites. Expand