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Running enhances neurogenesis, learning, and long-term potentiation in mice.
Running increases neurogenesis in the dentate gyrus of the hippocampus, a brain structure that is important for memory function. Consequently, spatial learning and long-term potentiation (LTP) wereExpand
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Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice
Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning. We investigatedExpand
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Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also known toExpand
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Running enhances spatial pattern separation in mice
Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms ofExpand
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Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
The dentate gyrus of the hippocampus contains neural progenitor cells (NPCs) that generate neurons throughout life. Developing neurons of the adult hippocampus have been described in depth. However,Expand
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Exercise and the brain: something to chew on.
Evidence is accumulating that exercise has profound benefits for brain function. Physical activity improves learning and memory in humans and animals. Moreover, an active lifestyle might prevent orExpand
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Monosynaptic inputs to new neurons in the dentate gyrus.
Adult hippocampal neurogenesis is considered important for cognition. The integration of newborn dentate gyrus granule cells into the existing network is regulated by afferent neuronal activity ofExpand
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Running is the neurogenic and neurotrophic stimulus in environmental enrichment.
Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and brain-derived neurotrophic factor (BDNF) levels. However, running is considered an element of EE. To dissociate effects ofExpand
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Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.
Peripheral processes that mediate beneficial effects of exercise on the brain remain sparsely explored. Here, we show that a muscle secretory factor, cathepsin B (CTSB) protein, is important for theExpand
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Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of aExpand
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